Title:
NOVEL COMPOUND COMPRISING ESTER GROUP AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/014119
Kind Code:
A1
Abstract:
The present invention relates to a novel compound comprising an ester group and uses thereof and, more particularly, to a novel compound that exhibits excellent visualization ability in a tumor by using the difference in activity of esterase for each organ in the body, and to uses therefor for diagnosing or treating cancer. A novel compound of chemical formulas 1 to 8 according to the present invention exhibits selectivity according to the difference in activity of esterase for each organ due to ester residue in a structure, and thus is extremely effective in visualizing pancreatic cancer, etc.
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Inventors:
YOO JEONGSOO (KR)
ABHINAV SUNIL BHISE (KR)
KIM KYUNGWON (KR)
LIM JEONGEUN (KR)
BYEON GYEONGTAK (KR)
ABHINAV SUNIL BHISE (KR)
KIM KYUNGWON (KR)
LIM JEONGEUN (KR)
BYEON GYEONGTAK (KR)
Application Number:
PCT/KR2022/011570
Publication Date:
February 09, 2023
Filing Date:
August 04, 2022
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
International Classes:
A61K51/12
Foreign References:
| KR20180132566A | 2018-12-12 | |||
| KR101754378B1 | 2017-07-05 | |||
| KR20210102453A | 2021-08-19 |
Other References:
MOHAMED E. EL‐ZARIA; NANCY JANZEN; MEGAN BLACKER; JOHN F. VALLIANT: "Synthesis, Characterisation, and Biodistribution of Radioiodinated C‐Hydroxy‐Carboranes", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 18, no. 35, 16 July 2012 (2012-07-16), DE, pages 11071 - 11078, XP071835954, ISSN: 0947-6539, DOI: 10.1002/chem.201200833
KUEFFER PETER J., MAITZ CHARLES A., KHAN ASLAM A., SCHUSTER SETH A., SHLYAKHTINA NATALIA I., JALISATGI SATISH S., BROCKMAN JOHN D.: "Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 16, 16 April 2013 (2013-04-16), pages 6512 - 6517, XP093032810, ISSN: 0027-8424, DOI: 10.1073/pnas.1303437110
NAKAMURA HIROYUKI, LEE JONG-DAE, UENO MANABU, MIYAJIMA YUSUKE, BAN HYUN SEUNG: "Synthesis of closo-Dodecaboryl Lipids and their Liposomal Formation for Boron Neutron Capture Therapy", NANOBIOTECHNOLOGY, HUMANA PRESS, TOTOWA, US, vol. 3, no. 2, 1 May 2007 (2007-05-01), US , pages 135 - 145, XP009543237, ISSN: 1551-1286, DOI: 10.1007/s12030-008-9000-6
LEE WOONGHEE, IL AN GWANG, PARK HYUN, SARKAR SWARBHANU, HA YEONG SU, HUYNH PHUONG TU, BHISE ABHINAV, BHATT NIKUNJ, AHN HEESU, PAND: "Imaging Strategy that Achieves Ultrahigh Contrast by Utilizing Differential Esterase Activity in Organs: Application in Early Detection of Pancreatic Cancer", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 11, 23 November 2021 (2021-11-23), US , pages 17348 - 17360, XP093032811, ISSN: 1936-0851, DOI: 10.1021/acsnano.1c05165
KUEFFER PETER J., MAITZ CHARLES A., KHAN ASLAM A., SCHUSTER SETH A., SHLYAKHTINA NATALIA I., JALISATGI SATISH S., BROCKMAN JOHN D.: "Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 16, 16 April 2013 (2013-04-16), pages 6512 - 6517, XP093032810, ISSN: 0027-8424, DOI: 10.1073/pnas.1303437110
NAKAMURA HIROYUKI, LEE JONG-DAE, UENO MANABU, MIYAJIMA YUSUKE, BAN HYUN SEUNG: "Synthesis of closo-Dodecaboryl Lipids and their Liposomal Formation for Boron Neutron Capture Therapy", NANOBIOTECHNOLOGY, HUMANA PRESS, TOTOWA, US, vol. 3, no. 2, 1 May 2007 (2007-05-01), US , pages 135 - 145, XP009543237, ISSN: 1551-1286, DOI: 10.1007/s12030-008-9000-6
LEE WOONGHEE, IL AN GWANG, PARK HYUN, SARKAR SWARBHANU, HA YEONG SU, HUYNH PHUONG TU, BHISE ABHINAV, BHATT NIKUNJ, AHN HEESU, PAND: "Imaging Strategy that Achieves Ultrahigh Contrast by Utilizing Differential Esterase Activity in Organs: Application in Early Detection of Pancreatic Cancer", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 11, 23 November 2021 (2021-11-23), US , pages 17348 - 17360, XP093032811, ISSN: 1936-0851, DOI: 10.1021/acsnano.1c05165
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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