Title:
NOVEL COMPOUND AND FUNCTIONAL LUMINESCENT PROBE COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2010/044465
Kind Code:
A1
Abstract:
Disclosed is a compound characterized by comprising a linker, an oxygen-concentration-responsive phosphorophore which is linked to a first end of the linker, and a fluorophore which is lined to a second end of the linker. In the compound, it is preferred that the triplet level of the phosphorophore be lower than that of the fluorophore. The compound can be used as an oxygen-responsive luminescent probe.
Inventors:
TOBITA SEIJI (JP)
YOSHIHARA TOSHITADA (JP)
HOSAKA MASAHIRO (JP)
TAKEUCHI TOSHIYUKI (JP)
YOSHIHARA TOSHITADA (JP)
HOSAKA MASAHIRO (JP)
TAKEUCHI TOSHIYUKI (JP)
Application Number:
PCT/JP2009/067919
Publication Date:
April 22, 2010
Filing Date:
October 16, 2009
Export Citation:
Assignee:
UNIV GUNMA NAT UNIV CORP (JP)
TOBITA SEIJI (JP)
YOSHIHARA TOSHITADA (JP)
HOSAKA MASAHIRO (JP)
TAKEUCHI TOSHIYUKI (JP)
TOBITA SEIJI (JP)
YOSHIHARA TOSHITADA (JP)
HOSAKA MASAHIRO (JP)
TAKEUCHI TOSHIYUKI (JP)
International Classes:
G01N31/22; G01N21/78; G01N31/00
Foreign References:
| JP2002501479A | 2002-01-15 | |||
| JP2003254909A | 2003-09-10 | |||
| JP2007049943A | 2007-03-01 | |||
| JP2007312688A | 2007-12-06 | |||
| JP2008281467A | 2008-11-20 | |||
| JP2008281467A | 2008-11-20 | |||
| JP2008185151A | 2008-08-14 | |||
| JP2008239660A | 2008-10-09 |
Other References:
RAYMOND P. BRINAS ET AL.: "Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna", J. AM. CHEM. SOC., vol. 127, no. 33, 2005, pages 11851 - 11862, XP008147001
YOSHIHARA ET AL.: "Iridium Sakutai no Shitsuon Rinko o Probe to suru Shishitsu Ni Bunshi Maku Chu no Sanso no Kyodo", ANNUAL MEETING OF JAPAN SOCIETY FOR MOLECULAR SCIENCE KOEN YOSHISHU, - 2007, pages 2C07, XP008147112
ROBERT B. BEST ET AL.: "Effect of flexibility and cis residues in single-molecule FRET studies of polyproline", PNAS, vol. 104, no. 48, 2007, pages 18964 - 18969, XP008147000
PARAMJIT S. ARORA ET AL.: "Design of Artificial Transcriptional Activators with Rigid Poly-L- proline Linkers", J. AM. CHEM. SOC., vol. 124, 2002, pages 13067 - 13071, XP007911805
S. LAMANSKY, P. DJUROVICH, D. MURPHY, F. ABDEL-RAZZAQ, H. LEE, C. ADACHI, P. E. BURROWS, S. R. FORREST, M. E. THOMPSON, J. AM. CHEM. SOC., vol. 123, 2001, pages 4303
H. KONNO, CHEM. TIMES, vol. 199, 2006, pages 13
M. NONOYAMA, BULL. CHEM. SOC. JPN., vol. 47, 1974, pages 767
S. SPROUSE, K. A. KING, P. J. SPELLANE, R. J. WATTS, J. AM. CHEM. SOC., vol. 106, 1984, pages 6647
See also references of EP 2348314A4
YOSHIHARA ET AL.: "Iridium Sakutai no Shitsuon Rinko o Probe to suru Shishitsu Ni Bunshi Maku Chu no Sanso no Kyodo", ANNUAL MEETING OF JAPAN SOCIETY FOR MOLECULAR SCIENCE KOEN YOSHISHU, - 2007, pages 2C07, XP008147112
ROBERT B. BEST ET AL.: "Effect of flexibility and cis residues in single-molecule FRET studies of polyproline", PNAS, vol. 104, no. 48, 2007, pages 18964 - 18969, XP008147000
PARAMJIT S. ARORA ET AL.: "Design of Artificial Transcriptional Activators with Rigid Poly-L- proline Linkers", J. AM. CHEM. SOC., vol. 124, 2002, pages 13067 - 13071, XP007911805
S. LAMANSKY, P. DJUROVICH, D. MURPHY, F. ABDEL-RAZZAQ, H. LEE, C. ADACHI, P. E. BURROWS, S. R. FORREST, M. E. THOMPSON, J. AM. CHEM. SOC., vol. 123, 2001, pages 4303
H. KONNO, CHEM. TIMES, vol. 199, 2006, pages 13
M. NONOYAMA, BULL. CHEM. SOC. JPN., vol. 47, 1974, pages 767
S. SPROUSE, K. A. KING, P. J. SPELLANE, R. J. WATTS, J. AM. CHEM. SOC., vol. 106, 1984, pages 6647
See also references of EP 2348314A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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