Title:
NOVEL COMPOUND HAVING LIPASE INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2005/123725
Kind Code:
A1
Abstract:
A novel polyphenol compound having lipase inhibitory activity and originating in
a tea; a process for producing the compound; and a food or beverage and a medicine each
containing the compound. The compound is a novel dimer compound, oolongtheanin 3'-O-gallate,
which is represented by the formula (1) and obtained by oxidatively polymerizing
epigallocatechin 3-O-gallate, which is the main catechin component of oolong
tea, with a tea enzyme (polyphenol oxidase). The food or beverage and the medicinal
composition each contains the novel compound, inhibits meal-derived fats from
being absorbed, and thereby inhibits the neutral-fat level in the blood from
increasing.
Inventors:
NAKAI MASAAKI (JP)
FUKUI YUKO (JP)
ASAMI SUMIO (JP)
FUKUI YUKO (JP)
ASAMI SUMIO (JP)
Application Number:
PCT/JP2005/011258
Publication Date:
December 29, 2005
Filing Date:
June 20, 2005
Export Citation:
Assignee:
SUNTORY LTD (JP)
NAKAI MASAAKI (JP)
FUKUI YUKO (JP)
ASAMI SUMIO (JP)
NAKAI MASAAKI (JP)
FUKUI YUKO (JP)
ASAMI SUMIO (JP)
International Classes:
A23F3/00; A23F3/16; A23F5/24; A23L1/30; A23L2/00; A23L2/52; A61K31/353; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P43/00; C07D407/14; (IPC1-7): C07D407/14; A23F3/00; A23L1/30; A23L2/00; A61K31/353; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P43/00
Foreign References:
| JP2000226329A | 2000-08-15 |
Other References:
ASHIMOTO H OKALA N. AND ISHIOKA N. ET AL.: "Tannins and related compounds. LXIX. Isolation and structure elucidation ofB.B´-linked bisflavanoids, theasinensins D-G and oolongtheanin from oolong tea. (2),", CHEMICAL PHARMACEUTICAL BULLETIN, vol. 36, no. 5, 1988, pages 1676 - 1684, XP002991752
ANAKA T. ET AL.: "Production of theasinensins A and D, epigallocatechin dimers of black tea, by oxidation-reduction distutation of dehydrotheasinensin A.", TETRAHEDRON, vol. 59, no. 40, 2003, pages 7939 - 7947, XP004458542
ASHIMOTO H. ANAKA G. AND ISHIOKA N. ET AL.: "Tannis and related compounds. CXI. Structures of novel fermentation products, theogallinin, theaflavonin and desgalloyl theaflavonin from black tea, and changes of tea leaf polyphenols during fermentation.", CHEMICAL PHARMACEUTICAL BULLETIN, vol. 40, no. 6, 1992, pages 1383 - 1389, XP002991753
SANG S. ET AL.: "Theadibenzotropolone A, a new type pigment from enzymatic oxidation of (-)-epicatechin and (-)-epigallocatechin gallate and characterized from black tea using LC/MS/MS.", TETRAHEDRON LETTERS, vol. 43, no. 40, 2002, pages 7129 - 7133, XP004385602
SANG S. ET AL.: "New dibenzotropolne derivativcs characterized from black tea using LC/MS/MS.", BIOORGANIC & MEDICINAL CHEMISTRY., vol. 12, no. 11, 1 June 2004 (2004-06-01), pages 3009 - 3017, XP002991754
See also references of EP 1783127A4
ANAKA T. ET AL.: "Production of theasinensins A and D, epigallocatechin dimers of black tea, by oxidation-reduction distutation of dehydrotheasinensin A.", TETRAHEDRON, vol. 59, no. 40, 2003, pages 7939 - 7947, XP004458542
ASHIMOTO H. ANAKA G. AND ISHIOKA N. ET AL.: "Tannis and related compounds. CXI. Structures of novel fermentation products, theogallinin, theaflavonin and desgalloyl theaflavonin from black tea, and changes of tea leaf polyphenols during fermentation.", CHEMICAL PHARMACEUTICAL BULLETIN, vol. 40, no. 6, 1992, pages 1383 - 1389, XP002991753
SANG S. ET AL.: "Theadibenzotropolone A, a new type pigment from enzymatic oxidation of (-)-epicatechin and (-)-epigallocatechin gallate and characterized from black tea using LC/MS/MS.", TETRAHEDRON LETTERS, vol. 43, no. 40, 2002, pages 7129 - 7133, XP004385602
SANG S. ET AL.: "New dibenzotropolne derivativcs characterized from black tea using LC/MS/MS.", BIOORGANIC & MEDICINAL CHEMISTRY., vol. 12, no. 11, 1 June 2004 (2004-06-01), pages 3009 - 3017, XP002991754
See also references of EP 1783127A4
Attorney, Agent or Firm:
SHAMOTO, Ichio et al. (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)
Download PDF:
Previous Patent: 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS
Next Patent: PYRIDINYL-ISOXAZOLES AND THEIR USE AS HERBICIDES
Next Patent: PYRIDINYL-ISOXAZOLES AND THEIR USE AS HERBICIDES