Title:
NOVEL COMPOUND HAVING LYSINE-SPECIFIC DEMETHYLATING ENZYME 1 INHIBITORY ACTIVITY, METHOD FOR PRODUCING SAME AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2019/009412
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the present invention relates to: a compound represented by formula (I) [in the formula, the meanings of L and A are as defined in the specification and claims], a stereoisomer thereof, a salt of the compound or the stereoisomer, or a solvate of the compound or the stereoisomer. Another embodiment of the present invention also relates to: a method for producing a compound represented by formula (I), a stereoisomer thereof or a salt of the compound or the stereoisomer, or a solvate of the compound or the stereoisomer; and an LSD1 inhibitor, a medicine and a pharmaceutical composition that contain said compound, the stereoisomer thereof, a salt of the compound or the stereoisomer, or a solvate of the compound or the stereoisomer as an effective component.
Inventors:
UMEHARA TAKASHI (JP)
SATO SHIN (JP)
KOYAMA HIROO (JP)
YAMAMOTO HIROFUMI (JP)
KONDO YUTAKA (JP)
KATSUSHIMA KEISUKE (JP)
FURUKAWA YUSUKE (JP)
KIKUCHI JIRO (JP)
KODA YASUKO (JP)
SATO SHIN (JP)
KOYAMA HIROO (JP)
YAMAMOTO HIROFUMI (JP)
KONDO YUTAKA (JP)
KATSUSHIMA KEISUKE (JP)
FURUKAWA YUSUKE (JP)
KIKUCHI JIRO (JP)
KODA YASUKO (JP)
Application Number:
PCT/JP2018/025702
Publication Date:
January 10, 2019
Filing Date:
July 06, 2018
Export Citation:
Assignee:
RIKEN (JP)
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
UNIV JICHI MEDICAL (JP)
UNIV NAGOYA NAT UNIV CORP (JP)
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
UNIV JICHI MEDICAL (JP)
UNIV NAGOYA NAT UNIV CORP (JP)
International Classes:
C07C217/74; A61K31/132; A61K31/337; A61K31/397; A61K31/40; A61K31/407; A61K31/4188; A61K31/437; A61K31/438; A61K31/495; A61K31/497; A61K31/4985; A61K31/4995; A61P35/00; A61P35/02; C07C213/08; C07C231/02; C07C237/04; C07C237/08; C07C237/10; C07C237/12; C07D205/04; C07D207/14; C07D209/14; C07D209/54; C07D211/26; C07D211/56; C07D211/58; C07D211/62; C07D213/36; C07D213/72; C07D217/06; C07D221/20; C07D231/40; C07D241/20; C07D271/06; C07D295/185; C07D295/192; C07D295/215; C07D305/08; C07D309/14; C07D401/04; C07D487/04; C07D487/08; C07D487/10; C07D491/107
Domestic Patent References:
| WO2010043721A1 | 2010-04-22 |
Foreign References:
| JP2014515013A | 2014-06-26 | |||
| JP2014532619A | 2014-12-08 | |||
| JP2015502335A | 2015-01-22 | |||
| JP2013535460A | 2013-09-12 | |||
| JP2013525331A | 2013-06-20 | |||
| CN106831489A | 2017-06-13 |
Other References:
MIMASU, SHINYA ET AL.: "Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1", BIOCHEMISTRY, vol. 49, no. 30, 2010, pages 6494 - 6503, XP055007918, DOI: 10.1021/bi100299r
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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