NOVEL COMPOUND HAVING MAILLARD REACTION INHIBITORY ACTIVITY

WIPO Patent Application WO/2002/060858

A1

A compound having strong inhibitory activity against the Maillard reaction; a medicine for use in the prevention of or treatments for diseases in which the Maillard reaction participates; and an additive for preventing the deterioration of cosmetics or foods caused by the Maillard reaction. The compound is one represented by the formula (I) or a pharmacologically acceptable salt thereof. (I) [In the formula, R?1¿ represents alkyl, cycloalkyl, aryl, unsaturated heterocycle, saturated heterocycle, or phenylalkenyl; R?3¿, R?4¿, R?5¿, and R?6¿ each represents hydrogen, OH, nitro, halogeno, alkyl, alkoxy, mercapto, alkylthio, amino, alkylamino, dialkylamino, or phenyl; R?8¿ represents hydrogen or represents a bond in cooperation with R?9¿; R?9¿ represents hydrogen, alkyl, etc.; and X represents a group (A) (wherein R?2a¿ represents alkyl, etc. and R?7a¿ represents hydrogen, alkyl, etc.), a group (B) (wherein R?2b¿ represents alkyl, etc. and Y represents oxo, etc.), or a group (C) (wherein R?2c¿ represents unsaturated heterocycle, etc., R?11c¿ and R?12c¿ each represents hydrogen, alkyl, etc., and n is an integer of 0 to 4).]

TSUTSUMI SEIJI (JP)
KAWAGUCHI MAMI (JP)
TADAUCHI KAORI (JP)
NINOMIYA TOMOHISA (JP)
YAHATA NAOKAZU (JP)
NAKATANI YUKO (JP)

PCT/JP2002/000786

August 08, 2002

January 31, 2002

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MEIJI SEIKA KAISHA (JP)
TSUTSUMI SEIJI (JP)
KAWAGUCHI MAMI (JP)
TADAUCHI KAORI (JP)
NINOMIYA TOMOHISA (JP)
YAHATA NAOKAZU (JP)
NAKATANI YUKO (JP)

A61P3/10; A61P9/00; A61P13/12; A61P19/02; A61P25/00; A61P25/28; A61P27/02; A61P43/00; C07C251/86; C07C309/73; C07C311/16; C07C311/17; C07C311/18; C07C311/19; C07D207/09; C07D207/16; C07D207/335; C07D211/44; C07D211/62; C07D213/38; C07D213/53; C07D213/70; C07D213/77; C07D213/86; C07D213/87; C07D213/88; C07D235/14; C07D235/28; C07D237/04; C07D239/38; C07D277/28; C07D277/64; C07D277/74; C07D295/125; C07D295/13; C07D295/145; C07D295/26; C07D307/52; C07D317/72; C07D333/22; C07D333/58; C07D495/04; C07D207/32; C07D235/10; (IPC1-7): C07C229/12; A23L1/30; A61K31/16; A61K31/166; A61K31/18; A61K31/19; A61K31/192; A61K31/22; A61K31/255; A61K31/341; A61K31/357; A61K31/381; A61K31/40; A61K31/401; A61K31/4184; A61K31/426; A61K31/428; A61K31/4365; A61K31/4402; A61K31/4409; A61K31/445; A61K31/4465; A61K31/465; A61K31/495; A61K31/505; A61K31/5375; A61P3/10; A61P9/00; A61P13/12; A61P19/02; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P43/00; C07C237/06; C07C243/28; C07C243/36; C07C243/38; C07C251/80; C07C309/73; C07C311/19; C07C311/46; C07D207/09; C07D207/16; C07D207/323; C07D211/46; C07D211/62; C07D213/53; C07D213/70; C07D213/81; C07D213/82; C07D235/28; C07D237/04; C07D239/38; C07D277/28; C07D277/64; C07D277/74; C07D295/12; C07D295/20; C07D295/22; C07D307/52; C07D317/72; C07D333/40; C07D333/70; C07D495/04

JPS4210212B1
US5066695A	1991-11-19
JPS59227858A	1984-12-21
GB1134589A	1968-11-27

SALERNI L.O. ET AL.: "New compounds: Preparation and hydrogenation of azomethines derived from 2,4-dihydroxyphenyl benzyl ketones", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 56, no. 12, 1967, pages 1684 - 1685, XP002952200
BERKESSEL A. ET AL.: "Pentacoordinated manganese (III) dihydrosalen complexes as biomimetic oxidation catalysts", JOURNAL OF MOLECULAR CATALYSIS A; CHEMICAL, vol. 113, 1996, pages 321 - 342, XP002952199

Yoshitake, Kenji (Fuji Bldg. 2-3 Marunouchi 3-chome Chiyoda-ku, Tokyo, JP)

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