Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL COMPOUND HAVING SMO INHIBITORY ACTIVITY AND COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2018/004213
Kind Code:
A1
Abstract:
The present invention relates to a novel compound having an SMO inhibitory activity, wherein the novel compound exhibits an excellent anticancer effect through abilities of isoindolinone and quinazolinone derivative compounds to modulate the hedgehog signaling pathway and inhibit SMO activity, and thus can prevent, alleviate, or treat a cancer disease.

Inventors:
LEE KYEONG (KR)
KO HYUK WAN (KR)
BHATTARAI DEEPAK (KR)
KIM MINKYOUNG (KR)
JUNG JOO HYUN (KR)
LEE HANKYU (KR)
Application Number:
PCT/KR2017/006692
Publication Date:
January 04, 2018
Filing Date:
June 26, 2017
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
DONGGUK UNIV INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C07D209/46; A61K31/4035; A61K31/517; A61K31/5377; C07D239/22; C07D413/14
Domestic Patent References:
WO2012016876A12012-02-09
WO2005021532A12005-03-10
WO2001019800A22001-03-22
WO2010084050A22010-07-29
Foreign References:
JPH07258224A1995-10-09
Other References:
BHATTARAI, D. O ET AL.: "Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 125, 19 October 2016 (2016-10-19), pages 1036 - 1050, XP029842463, DOI: doi:10.1016/j.ejmech.2016.10.040
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
Download PDF: