Title:
NOVEL COMPOUND HAVING THERAPEUTIC ACTIVITY AGAINST MYCOBACTERIUM AVIUM COMPLEX INFECTION, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2019/044941
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel compound that has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare, which are pathogens implicated in MAC infection, and has a backbone structure different from those of known MAC infection therapeutics. One embodiment of the present invention pertains to a compound represented by formula (I) (wherein R1 is as defined in the description or the claims), a salt thereof, or a solvate of either. Another embodiment of the present invention pertains to a method for producing the compound represented by formula (I), a salt thereof, or a solvate of either; and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), the agent containing said compound, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either as an active ingredient.
Inventors:
TOMODA HIROSHI (JP)
KOYAMA NOBUHIRO (JP)
KANAMOTO AKIHIKO (JP)
HASHIMOTO JUNKO (JP)
KOZONE IKUKO (JP)
KOYAMA NOBUHIRO (JP)
KANAMOTO AKIHIKO (JP)
HASHIMOTO JUNKO (JP)
KOZONE IKUKO (JP)
Application Number:
PCT/JP2018/032048
Publication Date:
March 07, 2019
Filing Date:
August 30, 2018
Export Citation:
Assignee:
THE KITASATO INST (JP)
OP BIO FACTORY CO LTD (JP)
JAPAN BIOLOGICAL INFORMATICS CONSORTIUM (JP)
OP BIO FACTORY CO LTD (JP)
JAPAN BIOLOGICAL INFORMATICS CONSORTIUM (JP)
International Classes:
C12P17/16; A61K31/7068; A61P31/04; C07H17/04; C12N1/20
Domestic Patent References:
| WO2013144894A1 | 2013-10-03 |
Foreign References:
| US3308117A | 1967-03-07 | |||
| US3309273A | 1967-03-14 | |||
| JP2010535797A | 2010-11-25 | |||
| JP2017168404A | 2017-09-21 |
Other References:
LICHTENTHALER, F. W. ET AL.: "Structural basis for inhibition of protein synthesis by the aminoacyl-aminohexosyl-cytosine group of antibiotics", FEBS LETTERS, vol. 38, no. 3, 1974, pages 237 - 242, XP055581147
TATSUOKA, SUEO ET AL: "Studies on Antibiotics. V:Extraction and Physicochemical Properties of Allomycin, an Antituberculous Antibiotic, and its Identity with Amicetin", YAKUGAKU ZASSHI JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 75, no. 10, 3 June 1955 (1955-06-03), pages 1206 - 1208, XP055581415
SUEO TATSUOKA, ET AL: "Studies on Antibiotics. VII Antagonistic Properties of Amicetin with Antifungal-Antiprotozoal Antibiotics in vitro", YAKUGAKU ZASSHI JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 75, no. 10, 3 June 1955 (1955-06-03), pages 1276 - 1281, XP055581419
BU, YING-YUE ET AL.: "Anti-mycobacterial nucleoside antibiotics from a marine-derived Streptomyces sp", TPU1236A, MARINE DRUGS, vol. 12, 2014, pages 6102 - 6112, XP002776301, DOI: 10.3390/md12126102
HOSODA KANJI ET AL : "26PA-pm104S: Separation and purification of active substances about mycobacterium avium complex produced by ocean-derived actinomycetes ", ABSTRACT OF THE 137TH ANNUAL CONFERENCE OF THE PHARMACEUTICAL SOCIETY OF JAPAN; 24-27/03/2017 , vol. 137, 1 March 2017 (2017-03-01), pages 223, XP009519324, ISSN: 0918-9823
HOSODA KANJI ET AL : "Study on searching novel antimicrobial substance with respect to mycobacterium avium complex using MS network technique "", LECTURE ABSTRACTS OF THE 32TH (2017) CONFERENCE OF THE SOCIETY FOR ACTINOMYCETES JAPAN ; 2017/9/7-2017/9/8, 7 September 2017 (2017-09-07), pages 67, XP009519322
TATSUOKA, SUEO ET AL: "Studies on Antibiotics. V:Extraction and Physicochemical Properties of Allomycin, an Antituberculous Antibiotic, and its Identity with Amicetin", YAKUGAKU ZASSHI JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 75, no. 10, 3 June 1955 (1955-06-03), pages 1206 - 1208, XP055581415
SUEO TATSUOKA, ET AL: "Studies on Antibiotics. VII Antagonistic Properties of Amicetin with Antifungal-Antiprotozoal Antibiotics in vitro", YAKUGAKU ZASSHI JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 75, no. 10, 3 June 1955 (1955-06-03), pages 1276 - 1281, XP055581419
BU, YING-YUE ET AL.: "Anti-mycobacterial nucleoside antibiotics from a marine-derived Streptomyces sp", TPU1236A, MARINE DRUGS, vol. 12, 2014, pages 6102 - 6112, XP002776301, DOI: 10.3390/md12126102
HOSODA KANJI ET AL : "26PA-pm104S: Separation and purification of active substances about mycobacterium avium complex produced by ocean-derived actinomycetes ", ABSTRACT OF THE 137TH ANNUAL CONFERENCE OF THE PHARMACEUTICAL SOCIETY OF JAPAN; 24-27/03/2017 , vol. 137, 1 March 2017 (2017-03-01), pages 223, XP009519324, ISSN: 0918-9823
HOSODA KANJI ET AL : "Study on searching novel antimicrobial substance with respect to mycobacterium avium complex using MS network technique "", LECTURE ABSTRACTS OF THE 32TH (2017) CONFERENCE OF THE SOCIETY FOR ACTINOMYCETES JAPAN ; 2017/9/7-2017/9/8, 7 September 2017 (2017-09-07), pages 67, XP009519322
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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