Title:
NOVEL COMPOUND FOR INHIBITING HISTONE ACETYLTRANSFERASE P300 AND ANTI-FIBROSIS COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2022/169284
Kind Code:
A1
Abstract:
The present invention relates to a novel compound which enables additional hydrogen bonding with amino acids at specific positions of histone acetyltransferase (HAT) p300 through the structural analysis of HAT p300. The novel compound according to the present invention has a remarkably excellent HAT p300 activity-inhibiting effect, and thus can be very effectively used to prevent, alleviate, or treat fibrosis, which is a disease associated with the activation of HAT p300.
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Inventors:
YOON HO GEUN (KR)
KWON YOUNGJOO (KR)
NA YOUNGHWA (KR)
SOHN MYUNG HYUN (KR)
YOO JUNG-YOON (KR)
KWON YOUNGJOO (KR)
NA YOUNGHWA (KR)
SOHN MYUNG HYUN (KR)
YOO JUNG-YOON (KR)
Application Number:
PCT/KR2022/001733
Publication Date:
August 11, 2022
Filing Date:
February 04, 2022
Export Citation:
Assignee:
REPURE LIFE SCIENCE INC (KR)
International Classes:
C07C223/06; A61K31/137; A61P43/00; C07C49/213; C07C233/76
Domestic Patent References:
| WO2001098291A2 | 2001-12-27 |
Foreign References:
| KR102085758B1 | 2020-03-06 | |||
| KR20050093826A | 2005-09-23 |
Other References:
DATABASE REGISTRY 2 July 1999 (1999-07-02), ANONYMOUS: "2-Propen-1-one, 3-[4-(3,5-diaminophenoxy)phenyl]-1-phenyl- (CA INDEX NAME)", XP055956103, retrieved from STN Database accession no. 226920-38-3
CHEN YI-PING; ZHANG ZI-YING; LI YAN-PING; LI DING; HUANG SHI-LIANG; GU LIAN-QUAN; XU JUN; HUANG ZHI-SHU: "Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, 1 August 2013 (2013-08-01), AMSTERDAM, NL , pages 22 - 31, XP028685912, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2013.05.015
CHEN YI-PING; ZHANG ZI-YING; LI YAN-PING; LI DING; HUANG SHI-LIANG; GU LIAN-QUAN; XU JUN; HUANG ZHI-SHU: "Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, 1 August 2013 (2013-08-01), AMSTERDAM, NL , pages 22 - 31, XP028685912, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2013.05.015
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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