Title:
NOVEL COMPOUND INHIBITING LYSINE-SPECIFIC DEMETHYLATING ENZYME 1, METHOD FOR PRODUCING SAME, AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2020/138398
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel compound exhibiting a high LSD1-inhibiting activity, high selectivity for LSD1 inhibition, and/or having a useful therapeutic effect for various diseases. One embodiment pertains to a compound represented by formula (I) [In the formula, Ar1, n, X2, X3, X4, R25, L and A are as defined in the specification and the claims], a stereoisomer thereof or salts thereof, or solvates thereof. Another embodiment pertains to: methods for producing a compound represented by formula (I), a stereoisomer thereof or salts thereof, or solvates thereof; and an LSD1 inhibitor, a pharmaceutical agent or a pharmaceutical composition that include, as an effective component, said compound, a stereoisomer thereof or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof.
Inventors:
UMEHARA TAKASHI (JP)
SATO SHIN (JP)
YAMAMOTO HIROFUMI (JP)
KODA YASUKO (JP)
KONDO YUTAKA (JP)
SHINJO KEIKO (JP)
SATO SHIN (JP)
YAMAMOTO HIROFUMI (JP)
KODA YASUKO (JP)
KONDO YUTAKA (JP)
SHINJO KEIKO (JP)
Application Number:
PCT/JP2019/051371
Publication Date:
July 02, 2020
Filing Date:
December 27, 2019
Export Citation:
Assignee:
RIKEN (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
C07C217/54; A61K31/135; A61K31/4045; A61K31/44; A61K31/4409; A61K31/4433; A61K31/4439; A61K31/444; A61K31/445; A61K31/4465; A61K31/4468; A61K31/4545; A61K31/495; A61K31/496; A61K31/4995; A61K31/5377; A61K31/5386; A61P35/00; C07C213/02; C07D209/14; C07D211/58; C07D213/38; C07D213/61; C07D231/12; C07D295/185; C07D401/12; C07D401/14; C07D405/12; C07D413/12; C07D471/10; C07D487/08; C07D487/10; C07D498/08
Domestic Patent References:
| WO2010043721A1 | 2010-04-22 | |||
| WO2019009412A1 | 2019-01-10 |
Foreign References:
| JP2014515013A | 2014-06-26 | |||
| JP2014532619A | 2014-12-08 | |||
| JP2019014683A | 2019-01-31 |
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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