Title:
NOVEL COMPOUND, AND MRI CONTRAST MEDIUM TO BE USED IN DIAGNOSIS AND TREATMENT OF INFLAMMATORY DISEASES AND CANCER, CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2024/063529
Kind Code:
A1
Abstract:
The present invention relates to a novel compound and an MRI contrast medium comprising same, the compound having, as a functional group, flavonoids, which are one of natural products having anti-inflammatory, antioxidant and anti-cancer effects. The novel compound of the present invention can be intravenously administered on the basis of having a superior solubility, which differs from that of a conventional insoluble flavonoid, can be expected to exhibit antioxidant, anti-inflammatory and anti-cancer effects even in a small amount and can be used as an T 1 MRI contrast medium, which targets inflammatory diseases and cancer and enables simultaneous diagnosis and treatment thereof.
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Inventors:
CHANG YONG MIN (KR)
YANG BYEONG WOO (KR)
YANG BYEONG WOO (KR)
Application Number:
PCT/KR2023/014251
Publication Date:
March 28, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
THERANOCURE CO LTD (KR)
International Classes:
A61K49/10; C07F5/00
Foreign References:
| KR101502180B1 | 2015-03-12 | |||
| KR102386595B1 | 2022-04-14 | |||
| KR20180011264A | 2018-01-31 | |||
| CN114981279A | 2022-08-30 |
Other References:
ATKINSON P; FINDLAY K S; KIELAR F; PAL R; PARKER D; POOLE R A; PUSCHMANN H; RICHARDSON S L; STENSON P A; THOMPSON A L; YU J: "Azaxanthones and azathioxanthones are effective sensitisers for europium and terbium luminescence", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 4, 23 March 2006 (2006-03-23), pages 1707 - 1722, XP002389777, ISSN: 1477-0520, DOI: 10.1039/b601357k
MUTHURAJAN THENMOZHI, RAMMANOHAR POOJA, RAJENDRAN NISHA PALANISAMY, SETHURAMAN SWAMINATHAN, KRISHNAN UMA MAHESWARI: "Evaluation of a quercetin–gadolinium complex as an efficient positive contrast enhancer for magnetic resonance imaging", RSC ADVANCES, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 5, no. 106, 1 January 2015 (2015-01-01), GB , pages 86967 - 86979, XP093149470, ISSN: 2046-2069, DOI: 10.1039/C5RA16405B
YANG BYEONG WOO, YANG SOHYEON, KIM SOYEON, BAEK AH RUM, SUNG BOKYUNG, KIM YEOUN-HEE, LEE JUNG TAE, LEE SANG YUN, KIM HEE-KYUNG, CH: "Flavonoid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents", ANTIOXIDANTS, MDPI AG, vol. 11, no. 12, 15 December 2022 (2022-12-15), pages 2470, XP093149471, ISSN: 2076-3921, DOI: 10.3390/antiox11122470
MUTHURAJAN THENMOZHI, RAMMANOHAR POOJA, RAJENDRAN NISHA PALANISAMY, SETHURAMAN SWAMINATHAN, KRISHNAN UMA MAHESWARI: "Evaluation of a quercetin–gadolinium complex as an efficient positive contrast enhancer for magnetic resonance imaging", RSC ADVANCES, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 5, no. 106, 1 January 2015 (2015-01-01), GB , pages 86967 - 86979, XP093149470, ISSN: 2046-2069, DOI: 10.1039/C5RA16405B
YANG BYEONG WOO, YANG SOHYEON, KIM SOYEON, BAEK AH RUM, SUNG BOKYUNG, KIM YEOUN-HEE, LEE JUNG TAE, LEE SANG YUN, KIM HEE-KYUNG, CH: "Flavonoid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents", ANTIOXIDANTS, MDPI AG, vol. 11, no. 12, 15 December 2022 (2022-12-15), pages 2470, XP093149471, ISSN: 2076-3921, DOI: 10.3390/antiox11122470
Attorney, Agent or Firm:
NAM, Gun Pil et al. (KR)
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