NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR TREATING NEUROLOGICAL DISORDERS

WIPO Patent Application WO/2020/122609

A1

The present invention relates to the production of a novel compound usable as a main ingredient of a pharmaceutical composition for preventing or treating neurological disorders, the compound being 9-deoxo-31-O-demethyl-prolyl-FK506, 9-deoxo-36,37-dihydro-FK506, 31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-FK520, 31-O-demethyl-FK520, 9-deoxo-31-O-demethyl-FK520, 9-deoxo-FK523, or 9-deoxo-31-O-demethyl-FK523. In addition, the present invention relates to a use of same in the prevention or treatment of neurological disorders.

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YOON YEO JOON (KR)
CHEONG EUNJI (KR)
BAHN YONG-SUN (KR)
YOON SEONG JUN (KR)
KANG SANG HYEON (KR)
JUN SOO YOUN (KR)
KWON AN SUNG (KR)
YOO YOUNG JI (KR)
SONG MYOUNG-CHONG (KR)
BEOM JI YOON (KR)
JUNG JIN A (KR)
LEE SOOJUNG (KR)
HWANGBO AREUM (KR)
LEE KYUNG-TAE (KR)

PCT/KR2019/017519

June 18, 2020

December 11, 2019

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INTRON BIOTECHNOLOGY CO LTD (KR)
UNIV EWHA IND COLLABORATION (KR)
UNIV YONSEI IACF (KR)

C07D519/00; A61K31/407; A61K31/4353; A61P25/00; C12P17/18

KR20060125916A	2006-12-06
KR20050071491A	2005-07-07
US5604234A	1997-02-18
KR20120019360A	2012-03-06

GOULET, M. T. ET AL.: "ALKYL ETHER DERIVATIVES OF THE FK-506 RELATED , IMMUNOSUPPRESSIVE MACROLIDE L-683 , 742 (C3 1 -O-DESMETHYL ASCOMYCIN", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 7, 1994, pages 927 - 930, XP026646494, DOI: 10.1016/S0960-894X(01)80265-1

SON, Min (KR)

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