Title:
NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION FOR TREATING FUNGAL INFECTION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2020/122607
Kind Code:
A1
Abstract:
The present invention relates to the preparation of novel compounds 9-deoxo-31-O-demethyl-prolyl-FK506, 9-deoxo-36,37-dihydro-FK506, 31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-FK520, 31-O-demethyl-FK520, 9-deoxo-31-O-demethyl-FK520, 9-deoxo-FK523, or 9-deoxo-31-O-demethyl-FK523, which can be used as a major component of a composition for treating fungal infection, and an antifungal use thereof.
Inventors:
YOON YEO JOON (KR)
BAHN YONG-SUN (KR)
CHEONG EUNJI (KR)
YOON SEONG JUN (KR)
KANG SANG HYEON (KR)
JUN SOO YOUN (KR)
KWON AN SUNG (KR)
YOO YOUNG JI (KR)
SONG MYOUNG-CHONG (KR)
BEOM JI YOON (KR)
JUNG JIN A (KR)
LEE KYUNG-TAE (KR)
LEE SOOJUNG (KR)
LEE YEONSEON (KR)
HWANGBO AREUM (KR)
HONG JOOHYEON (KR)
BAHN YONG-SUN (KR)
CHEONG EUNJI (KR)
YOON SEONG JUN (KR)
KANG SANG HYEON (KR)
JUN SOO YOUN (KR)
KWON AN SUNG (KR)
YOO YOUNG JI (KR)
SONG MYOUNG-CHONG (KR)
BEOM JI YOON (KR)
JUNG JIN A (KR)
LEE KYUNG-TAE (KR)
LEE SOOJUNG (KR)
LEE YEONSEON (KR)
HWANGBO AREUM (KR)
HONG JOOHYEON (KR)
Application Number:
PCT/KR2019/017517
Publication Date:
June 18, 2020
Filing Date:
December 11, 2019
Export Citation:
Assignee:
INTRON BIOTECHNOLOGY CO LTD (KR)
UNIV EWHA IND COLLABORATION (KR)
UNIV YONSEI IACF (KR)
UNIV EWHA IND COLLABORATION (KR)
UNIV YONSEI IACF (KR)
International Classes:
C07D498/12; A61K31/407; A61K31/4375; A61P31/10; C12P17/18
Domestic Patent References:
| WO2011068341A2 | 2011-06-09 | |||
| WO1991002736A1 | 1991-03-07 |
Foreign References:
| KR20010085877A | 2001-09-07 |
Other References:
YEONSEON LEE, ET AL: "In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 62, no. 11, 4 September 2018 (2018-09-04), US, pages 1 - 17, XP055718962, ISSN: 0066-4804, DOI: 10.1128/AAC.01627-18
PARK, J.W. ; MO, S.J. ; PARK, S.R. ; BAN, Y.H. ; YOO, Y.J. ; YOON, Y.J.: "Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 393, no. 1, 1 October 2009 (2009-10-01), Amsterdam, NL, pages 1 - 7, XP026419315, ISSN: 0003-2697
PARK, J.W. ; MO, S.J. ; PARK, S.R. ; BAN, Y.H. ; YOO, Y.J. ; YOON, Y.J.: "Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 393, no. 1, 1 October 2009 (2009-10-01), Amsterdam, NL, pages 1 - 7, XP026419315, ISSN: 0003-2697
Attorney, Agent or Firm:
SON, Min (KR)
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