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Title:
NOVEL COMPOUND AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/131171
Kind Code:
A1
Abstract:
Provided is a compound represented by general formula (I) and a pharmaceutically acceptable salt thereof. [In formula (I): A1 is a methylene group, and the like; A2 is a methylene group or an oxygen atom; A3 is an azetidinyl group, pyrrolidinyl group, piperidinyl group, piperazinyl group, or homopiperazinyl group optionally substituted by -N(R1)R2, -N(R1)R3, and/or -R3; A4 is -O-, -S-, -S(O)-, -S(O)2-, or -N(R1)-; A5 is an optionally substituted C3-10 cycloalkylalkyl group, and the like; R4 is a halogen atom, and the like; and n is an integer of 0 or 1.]

Inventors:
ARAI MAMI (JP)
YAMAKAWA TAKERU (JP)
NAKAJIMA RIE (JP)
MURASAKI KOTA (JP)
WAKIYAMA YOSHINARI (JP)
FUJIWARA YUTA (JP)
ISHIKAWA MAKOTO (JP)
NINOMIYA TOMOHISA (JP)
Application Number:
JP2017/002975
Publication Date:
August 03, 2017
Filing Date:
January 27, 2017
Export Citation:
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Assignee:
MEIJI SEIKA PHARMA CO LTD (JP)
International Classes:
C07D239/95; A61K31/517; A61K31/519; A61K31/551; A61P1/04; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P37/08; A61P43/00; C07D401/12; C07D403/04; C07D403/12; C07D405/12; C07D409/12; C07D417/14; C07D491/048; C07D495/04
Domestic Patent References:
WO2008060767A22008-05-22
WO2005014556A12005-02-17
WO2005054239A12005-06-16
WO2005100341A12005-10-27
WO2008060766A22008-05-22
WO2008074445A12008-06-26
Foreign References:
JPH09502449A1997-03-11
Other References:
SMITS,R.A. ET AL.: "Discovery of Quinazolines as Histamine H 4 Receptor Inverse Agonists Using a Scaffold Hopping Approach", J.MED.CHEM., vol. 51, 2008, pages 7855 - 7865, XP055025337
WAGNER,E. ET AL.: "MepyramineJNJ7777120-hybrid compounds show high affinity to hHR, but low affinity to hHR", BIOORG.MED.CHEM.LETT., vol. 21, 2011, pages 6274 - 6280, XP028308755
See also references of EP 3409662A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Patent business corporation cent Crest international patent firm (JP)
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