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Title:
NOVEL COMPOUND PROMOTIVE OF OSTEOBLAST DIFFERENTIATION AND INHIBITORY OF ADIPOSE CELL DIFFERENTIATION, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/209410
Kind Code:
A1
Abstract:
The present invention relates to a compound having the activity of promoting the differentiation of osteoblasts and inhibiting the differentiation of adipose cells, and a preparation method therefor. A novel compound of the present invention increases the expression of the gene ALP involved in the differentiation of osteoblasts, regulates the expression of the genes PPARγ, aP2, and CD36 involved in the differentiation of adipose cells, increases a bone mass density (BMD)in an ovariectomized osteoporous animal model, and decreases a level of adipose cells in the bone marrow. Thus, the compound can be used as an effective ingredient of medications or health functional foods for bone metabolic diseases or obesity.

Inventors:
KIM, Hyun Suk (405 3, Ichon-ro 88-gilYongsan-gu, Seoul, 04425, KR)
PARK, Kimoon (1410-1103, 60 Pangyowon-ro 82beon-gil,Seongnam-si, Gyeonggi-do, 13540, KR)
BANG, Min-hyuk (102-707, 386 Seowon-ro, Wansan-gu,Jeonju-si, Jeollabuk-do, 55046, KR)
YANG, Hee-Jin (101-404, 10 Saimdang-ro 19-gil,Seocho-gu, Seoul, 06637, KR)
LEE, Yun Mi (101-2204, 49 Seokgye-ro,Nowon-gu, Seoul, 01901, KR)
KIM, Ki Hyun (15-1, Guambuk 14-gil Masanhoewon-gu,Changwon-si, Gyeongsangnam-do, 51204, KR)
Application Number:
KR2017/004972
Publication Date:
December 07, 2017
Filing Date:
May 12, 2017
Export Citation:
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Assignee:
SUNG KYUN BIOTECH CO., LTD. (#6054, #6055 81 Neungan-ro, Danwon-gu,Ansan-si, Gyeonggi-do, 15425, KR)
International Classes:
A61K31/34; A23L33/10
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (Bethel Bldg. 8F, 23 Dongsan-ro,Seocho-gu, Seoul, 06779, KR)
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