Title:
NOVEL COMPOUND PROMOTIVE OF OSTEOBLAST DIFFERENTIATION AND INHIBITORY OF ADIPOSE CELL DIFFERENTIATION, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/209410
Kind Code:
A1
Abstract:
The present invention relates to a compound having the activity of promoting the differentiation of osteoblasts and inhibiting the differentiation of adipose cells, and a preparation method therefor. A novel compound of the present invention increases the expression of the gene ALP involved in the differentiation of osteoblasts, regulates the expression of the genes PPARγ, aP2, and CD36 involved in the differentiation of adipose cells, increases a bone mass density (BMD)in an ovariectomized osteoporous animal model, and decreases a level of adipose cells in the bone marrow. Thus, the compound can be used as an effective ingredient of medications or health functional foods for bone metabolic diseases or obesity.
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Inventors:
KIM HYUN SUK (KR)
PARK KIMOON (KR)
BANG MIN-HYUK (KR)
YANG HEE-JIN (KR)
LEE YUN MI (KR)
KIM KI HYUN (KR)
PARK KIMOON (KR)
BANG MIN-HYUK (KR)
YANG HEE-JIN (KR)
LEE YUN MI (KR)
KIM KI HYUN (KR)
Application Number:
PCT/KR2017/004972
Publication Date:
December 07, 2017
Filing Date:
May 12, 2017
Export Citation:
Assignee:
SUNG KYUN BIOTECH CO LTD (KR)
International Classes:
A61K31/34; A23L33/10
Foreign References:
| KR20150055667A | 2015-05-22 |
Other References:
LU , F. ET AL.: "Preparation and relevance of a cross-coupling product between sinapyl alcohol and sinapyl p-hydroxybenzoate", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 2, no. 20, November 2004 (2004-11-01), pages 2888 - 2890, XP055599278
LEE, I.-S.: "Phenolic compounds from the leaves and twigs of Osteomeles schwerinae that inhibit rat lens aldose reductase and vessel dilation in zebrafish larvae", JOURNAL OF NATURAL PRODUCTS, vol. 78, no. 9, 2015, pages 2249 - 2254, XP055599281
YAMAUCHI, S.: "Structure-plant phytotoxic activity relationship of 7,7v-epoxylignanes, (+)- and (-)-verrucosin: Simplification on the aromatic ring substituents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, no. 20, 15 October 2014 (2014-10-15), pages 4798 - 4803, XP029048255
JOHNSON, T. A. ET AL.: "Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders", PHYTOMEDICINE, vol. 20, no. 2, 1 January 2013 (2013-01-01), pages 143 - 147, XP055599289
LEE, I.-S.: "Phenolic compounds from the leaves and twigs of Osteomeles schwerinae that inhibit rat lens aldose reductase and vessel dilation in zebrafish larvae", JOURNAL OF NATURAL PRODUCTS, vol. 78, no. 9, 2015, pages 2249 - 2254, XP055599281
YAMAUCHI, S.: "Structure-plant phytotoxic activity relationship of 7,7v-epoxylignanes, (+)- and (-)-verrucosin: Simplification on the aromatic ring substituents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, no. 20, 15 October 2014 (2014-10-15), pages 4798 - 4803, XP029048255
JOHNSON, T. A. ET AL.: "Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders", PHYTOMEDICINE, vol. 20, no. 2, 1 January 2013 (2013-01-01), pages 143 - 147, XP055599289
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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