Title:
NOVEL COMPOUND, AND REAGENT FOR DETECTING LIPID DROPLETS AND/OR ADIPOSE TISSUE CONTAINING SAID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/142320
Kind Code:
A1
Abstract:
Provided is a compound represented by general formula (I) and capable of detecting lipid droplets and/or adipose tissue. (In formula (I), R1 represents a C1-4 alkyl group, R2 represents a C1-4 alkyl group, and X is a group represented by formula (II), where R5's each independently represent NO2, a halogen atom, a C1-4 alkyl group in which at least one hydrogen atom has been substituted by a halogen atom, a -C(=O)-C1-4 alkyl group, or CN, and n represents an integer of 1-5, with the proviso that the electron density of carbon atoms at position 1 of the benzene ring in formula (II) is within the -0.240 to -0.190 range)).
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Inventors:
ABE HIROSHI (JP)
ITO MIKA (JP)
ITO YOSHIHIRO (JP)
NISHIMURA SATOSHI (JP)
ITO MIKA (JP)
ITO YOSHIHIRO (JP)
NISHIMURA SATOSHI (JP)
Application Number:
PCT/JP2014/056973
Publication Date:
September 18, 2014
Filing Date:
March 14, 2014
Export Citation:
Assignee:
RIKEN (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
C07D265/34; A61K49/00; G01N33/15; G01N33/50
Foreign References:
| JP2008523379A | 2008-07-03 |
Other References:
BONILLA E ET AL.: "Application of nile blue and nile red, two fluorescent probes, for detection of lipid droplets in human skeletal muscle", THE JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, vol. 35, no. 5, 1987, pages 619 - 621
P GREENSPAN ET AL.: "Spectrofluorometric studies of the lipid probe, nile red.", THE JOURNAL OF LIPID RESEARCH, vol. 26, no. 7, 1985, pages 781 - 789, XP002459744
JIE ZHANG ET AL.: "Synthesis and Characterization of a Series of Highly FluorogenicSubstrates for Glutathione Transferases, a General Strategy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 35, 2011, pages 14109 - 14119, XP055062761, DOI: doi:10.1021/ja205500y
JINEY JOSE ET AL.: "Benzophenoxazine-based fluorescent dyes for labeling biomolecules", TETRAHEDRON, vol. 62, no. 48, 2006, pages 11021 - 11037
WU LIU ET AL.: "Reversible Near-Infrared pH Probes Based on Benzo[a]phenoxazine", ANALYTICAL CHEMISTRY, vol. 85, no. 15, pages 7419 - 7425
P GREENSPAN ET AL.: "Spectrofluorometric studies of the lipid probe, nile red.", THE JOURNAL OF LIPID RESEARCH, vol. 26, no. 7, 1985, pages 781 - 789, XP002459744
JIE ZHANG ET AL.: "Synthesis and Characterization of a Series of Highly FluorogenicSubstrates for Glutathione Transferases, a General Strategy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 35, 2011, pages 14109 - 14119, XP055062761, DOI: doi:10.1021/ja205500y
JINEY JOSE ET AL.: "Benzophenoxazine-based fluorescent dyes for labeling biomolecules", TETRAHEDRON, vol. 62, no. 48, 2006, pages 11021 - 11037
WU LIU ET AL.: "Reversible Near-Infrared pH Probes Based on Benzo[a]phenoxazine", ANALYTICAL CHEMISTRY, vol. 85, no. 15, pages 7419 - 7425
Attorney, Agent or Firm:
TSUJII Koichi et al. (JP)
辻居 Koichi (JP)
辻居 Koichi (JP)
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