Title:
NOVEL COMPOUND FOR SIMULTANEOUSLY GENERATING CINNAM ALDEHYDE AND QUINONE METHIDE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/056742
Kind Code:
A1
Abstract:
The present invention relates to a compound for simultaneously generating cinnam aldehyde and quinone methide. In the presence of esterase and in acidic pH conditions, the compound of the present invention releases both cinnam aldehyde that generates ROS and quinone methide that elimanates GSH, and thus can be usefully employed in the prevention or treatment of cancer as the compound inhibits an antioxidation system and promotes apoptosis, and thereby cancer cell-specifically causes a double stimulus reaction and a synergy anticancer effect.
Inventors:
LEE DONG WON (KR)
HAN EUN JI (KR)
YOO DONG HYUCK (KR)
HAN EUN JI (KR)
YOO DONG HYUCK (KR)
Application Number:
PCT/KR2017/010454
Publication Date:
March 29, 2018
Filing Date:
September 22, 2017
Export Citation:
Assignee:
NAT UNIV CHONBUK IND COOP FOUND (KR)
International Classes:
A61K31/357; A23L33/10
Domestic Patent References:
| WO2000033858A1 | 2000-06-15 | |||
| WO2005065361A2 | 2005-07-21 |
Foreign References:
| KR20150081415A | 2015-07-14 | |||
| KR20100000553A | 2010-01-06 |
Other References:
HAN, E. ET AL.: "Dual Stimuli-Activatabie Oxidative Stress Amplifying Agent as a Hybrid Anticancer Prodrug", BIOCONJUGATE CHEMISTRY, vol. 28, no. 4, 13 February 2017 (2017-02-13), pages 968 - 978, XP055482802
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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