Title:
NOVEL COMPOUND WITH ANTIBACTERIAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2014/171527
Kind Code:
A1
Abstract:
A compound or a salt thereof represented by general formula (I) with a strong antibacterial activity against bacteria that have developed resistance to quinolones, a medicine for preventing and/or treating an infectious disease which comprises the compound or a salt thereof as an active ingredient, and a medicine for preventing and/or treating an infectious disease which comprises a combination of the compound or a salt thereof and quinolones.
Inventors:
HIRAMATSU KEIICHI (JP)
MORIMOTO YUH (JP)
BABA TADASHI (JP)
HAYAKAWA ISAO (JP)
MORIMOTO YUH (JP)
BABA TADASHI (JP)
HAYAKAWA ISAO (JP)
Application Number:
PCT/JP2014/061004
Publication Date:
October 23, 2014
Filing Date:
April 18, 2014
Export Citation:
Assignee:
JUNTENDO EDUCATIONAL FOUNDATION (JP)
International Classes:
C07D215/22; A61K31/4704; A61K45/00; A61P31/04; A61P43/00; C07D401/04; C07D403/04; C07D491/056; C07D498/04; C07D498/06; C12N9/99
Domestic Patent References:
| WO2006137485A1 | 2006-12-28 | |||
| WO2011058923A1 | 2011-05-19 | |||
| WO2012108376A1 | 2012-08-16 |
Foreign References:
| JP2013043859A | 2013-03-04 | |||
| JP2003146972A | 2003-05-21 | |||
| EP2130831A1 | 2009-12-09 | |||
| JPH09507879A | 1997-08-12 | |||
| US20030105124A1 | 2003-06-05 | |||
| JP2008502720A | 2008-01-31 |
Other References:
MAITI, ARUP ET AL.: "Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 7, 2009, pages 1873 - 1884, XP055291466
MEISELS, ALEX ET AL.: "The constituents of Casimiroa edulis. III. The structure of casimiroin", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 79, 1957, pages 6328 - 6333, XP055291468
CHILIN, ADRIANA ET AL.: "4-Hydroxymethyl- and 4-methoxymethylfuro[2,3-h]quinolin-2(1H)-ones: synthesis and biological properties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 7, 2003, pages 1311 - 1318, XP055291469
MARZANO, CRISTINA ET AL.: "1,4,8-Trimethylfuro [2,3-H]quinolin-2(lH)-one, a new furocoumarin bioisoster", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, no. 5, 2004, pages 411 - 419, XP004505034
MOHAMED, E. A. ET AL.: "Synthesis of some 1,10- phenanthroline derivatives", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 72, no. 2, 1995, pages 93 - 97
PATHAK, L. P. ET AL.: "2-nitro-6,11-dioxo-6,11- dihydro-5H-dibenzo[b,e]azepin-4-yl-alkyl- arylamides/imides as possible hypoglycemic agents", INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 17, no. 4, 2008, pages 373 - 374
NADZAN, ALEX M. ET AL.: "Hydroxynybomycin: isolation, structure and bioactivity", JOURNAL OF ANTIBIOTICS, vol. 30, no. 6, 1977, pages 523 - 524, XP008156820
EBLE, T. E. ET AL.: "Nybomycin: isolation, properties, and derivatives", ANTIBIOTICS AND CHEMOTHERAPY, vol. 8, 1958, WASHINGTON , D. C., pages 627 - 630
See also references of EP 2987787A4
J. ANTIMICROB. CHEMOTHER., vol. 40, no. 1, 1997, pages 135 - 136
ANTIMICROB. AGENTS CHEMOTHER., vol. 53, no. 11, 2009, pages 4580 - 4587
INT. J. ANTIMICROB. AGENTS, vol. 39, no. 6, 2012, pages 478 - 485
XIAN-ZHI LI; HIROSHI NIKAIDO, DRUGS, vol. 69, 2009, pages 1555 - 1623
ANTIBIOTICS, vol. 2, 2013, pages 28 - 45
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 59, 2007, pages 1223 - 1229
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, 2011, pages 7679 - 7689
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 48, 2004, pages 4171 - 4176
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 59, 2007, pages 1247 - 1260
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 52, 2008, pages 3202 - 3209
JOURNAL OF THE JAPANESE SOCIETY OF CHEMOTHERAPY, vol. 52, no. 7, 2004, pages 355 - 360
PABN: PLOS ONE, vol. 8, 2013, pages E60666
J. ANTIMICROB. AGENTS., vol. 39, no. 6, 2012, pages 478 - 485
ANTIMICROB. AGENTS CHEMOTHER., vol. 42, no. 8, 1998, pages 1917 - 1922
CLIN. MICROBIOL., vol. 40, no. 11, 2002, pages 4289 - 4294
JOURNAL OF THE JAPANESE SOCIETY OF CHEMOTHERAPY, vol. 56, no. 1, 2008, pages 16 - 20
J. ANTIMICROB. AGENTS, vol. 39, no. 6, 2012, pages 478 - 485
METHODS MOL., MED., vol. 142, 2008, pages 11 - 23
ANTIMICROB. AGENTS CHEMOTHER., vol. 41, 1997, pages 2362 - 2366
INT. J. ANTIMICROB. AGENTS, vol. 39, no. 6, 2012, pages 478 - 85
ANTIMICROB. AGENTS CHEMOTHER., vol. 43, no. 5, 1999, pages 1129 - 36
MEISELS, ALEX ET AL.: "The constituents of Casimiroa edulis. III. The structure of casimiroin", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 79, 1957, pages 6328 - 6333, XP055291468
CHILIN, ADRIANA ET AL.: "4-Hydroxymethyl- and 4-methoxymethylfuro[2,3-h]quinolin-2(1H)-ones: synthesis and biological properties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 7, 2003, pages 1311 - 1318, XP055291469
MARZANO, CRISTINA ET AL.: "1,4,8-Trimethylfuro [2,3-H]quinolin-2(lH)-one, a new furocoumarin bioisoster", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, no. 5, 2004, pages 411 - 419, XP004505034
MOHAMED, E. A. ET AL.: "Synthesis of some 1,10- phenanthroline derivatives", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 72, no. 2, 1995, pages 93 - 97
PATHAK, L. P. ET AL.: "2-nitro-6,11-dioxo-6,11- dihydro-5H-dibenzo[b,e]azepin-4-yl-alkyl- arylamides/imides as possible hypoglycemic agents", INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 17, no. 4, 2008, pages 373 - 374
NADZAN, ALEX M. ET AL.: "Hydroxynybomycin: isolation, structure and bioactivity", JOURNAL OF ANTIBIOTICS, vol. 30, no. 6, 1977, pages 523 - 524, XP008156820
EBLE, T. E. ET AL.: "Nybomycin: isolation, properties, and derivatives", ANTIBIOTICS AND CHEMOTHERAPY, vol. 8, 1958, WASHINGTON , D. C., pages 627 - 630
See also references of EP 2987787A4
J. ANTIMICROB. CHEMOTHER., vol. 40, no. 1, 1997, pages 135 - 136
ANTIMICROB. AGENTS CHEMOTHER., vol. 53, no. 11, 2009, pages 4580 - 4587
INT. J. ANTIMICROB. AGENTS, vol. 39, no. 6, 2012, pages 478 - 485
XIAN-ZHI LI; HIROSHI NIKAIDO, DRUGS, vol. 69, 2009, pages 1555 - 1623
ANTIBIOTICS, vol. 2, 2013, pages 28 - 45
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 59, 2007, pages 1223 - 1229
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, 2011, pages 7679 - 7689
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 48, 2004, pages 4171 - 4176
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 59, 2007, pages 1247 - 1260
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 52, 2008, pages 3202 - 3209
JOURNAL OF THE JAPANESE SOCIETY OF CHEMOTHERAPY, vol. 52, no. 7, 2004, pages 355 - 360
PABN: PLOS ONE, vol. 8, 2013, pages E60666
J. ANTIMICROB. AGENTS., vol. 39, no. 6, 2012, pages 478 - 485
ANTIMICROB. AGENTS CHEMOTHER., vol. 42, no. 8, 1998, pages 1917 - 1922
CLIN. MICROBIOL., vol. 40, no. 11, 2002, pages 4289 - 4294
JOURNAL OF THE JAPANESE SOCIETY OF CHEMOTHERAPY, vol. 56, no. 1, 2008, pages 16 - 20
J. ANTIMICROB. AGENTS, vol. 39, no. 6, 2012, pages 478 - 485
METHODS MOL., MED., vol. 142, 2008, pages 11 - 23
ANTIMICROB. AGENTS CHEMOTHER., vol. 41, 1997, pages 2362 - 2366
INT. J. ANTIMICROB. AGENTS, vol. 39, no. 6, 2012, pages 478 - 85
ANTIMICROB. AGENTS CHEMOTHER., vol. 43, no. 5, 1999, pages 1129 - 36
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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