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Title:
NOVEL COMPOUNDS OF 11BETA-HYDROXY-STEROIDS FOR USE IN MITOCHONDRIA BIOGENESIS AND DISEASES ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION OR DEPLETION
Document Type and Number:
WIPO Patent Application WO/2014/115167
Kind Code:
A3
Abstract:
The present invention provides novel compounds of 11β-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitochondrial dysfunction or depletion, and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat, prevent, or reverse injury to or depletion of mitochondria.

Inventors:
DUGAR, Sundeep (Sphaera Pharma Pvt. Ltd, Plot No.32 Sector 5,,IMT Manesar, Haryana 1, 12205, IN)
SCHREINER, Frederic, George (12774 Leander Drive, Los Altos Hills, Ca California, 94022, US)
MAHAJAN, Dinesh (Sphaera Pharma Pvt. Ltd, Plot No.32 Sector 5,,IMT Manesar, Haryana 1, 12205, IN)
SHARMA, Amit (Sphaera Pharma Pvt. Ltd, Plot No.32 Sector 5,,IMT Manesar, Haryana 1, 12205, IN)
PATIL, Ishwar, Rakesh (Sphaera Pharma Pvt. Ltd, Plot No.32 Sector 5,,IMT Manesar, Haryana 1, 12205, IN)
KUILA, Bilash (Sphaera Pharma Pvt. Ltd, Plot No.32 Sector 5,,IMT Manesar, Haryana 1, 12205, IN)
Application Number:
IN2014/000048
Publication Date:
July 31, 2014
Filing Date:
January 23, 2014
Export Citation:
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Assignee:
SPHAERA PHARMA PVT. LTD. (Plot No.32, Sector 5,IMT Manesar, Haryana 1, 12205, IN)
International Classes:
A61K31/56; C07J5/00; C07J71/00
Domestic Patent References:
WO1988002753A21988-04-21
WO2004037251A12004-05-06
Other References:
See also references of EP 2948152A4
Attorney, Agent or Firm:
ARVIND, Chitra (Rajeshwari & Associates, Amsoft Business CentreUnitech Trade Centre,Sector 43, Gurgaon, Haryana 2, 12200, IN)
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