Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL COMPOUNDS AND DERIVATIZATION OF DNAS AND RNAS ON THE NUCLEOBASES OF PYRIMIDINES FOR FUNCTION, STRUCTURE, AND THERAPEUTICS
Document Type and Number:
WIPO Patent Application WO/2010/135564
Kind Code:
A3
Abstract:
Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of counducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.

Inventors:
HUANG, Zhen (Department ofChemistry,Room 540, 38 Peachtree Center Ave, Atlanta GA, 30303-3083, US)
HASSAN, Abdalla, E.a. (Department OfChemistry,Room 540, 38 Peachtree Center Ave, Atlanta GA, 30303-3083, US)
SHENG, Jia (1107 Lenox Park Circle, NeAtlanta, GA, 30319, US)
ZHANG, Wen (Department OfChemistry,Room 540, 38 Peachtree Center Ave, Atlanta GA, 30303-3083, US)
Application Number:
US2010/035631
Publication Date:
May 05, 2011
Filing Date:
May 20, 2010
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SENA RESEARCH, INC. (1560 Kinglet Lane, Marietta, GA, 30062, US)
GEORGIA STATE UNIVERSITY OFFICE OF LEGAL AFFAIRS (P.O. Box 3987, Atlanta, GA, 30302-3987, US)
HUANG, Zhen (Department ofChemistry,Room 540, 38 Peachtree Center Ave, Atlanta GA, 30303-3083, US)
HASSAN, Abdalla, E.a. (Department OfChemistry,Room 540, 38 Peachtree Center Ave, Atlanta GA, 30303-3083, US)
SHENG, Jia (1107 Lenox Park Circle, NeAtlanta, GA, 30319, US)
ZHANG, Wen (Department OfChemistry,Room 540, 38 Peachtree Center Ave, Atlanta GA, 30303-3083, US)
International Classes:
C07H19/06; C07H21/00
Domestic Patent References:
WO1992002258A11992-02-20
Foreign References:
DE2415812A11974-10-17
Other References:
THIVIYANATHAN, V. ET AL.: "Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 366, 15 August 2008 (2008-08-15), pages 752-757, XP002611974,
FUJIMOTO J ET AL: "SYNTHESIS AND CLEAVAGE OF OLIGODEOXYNUCLEOTIDES CONTAINING A 5- HYDROXYURACIL RESIDUE AT A DEFINED SITE", CHEMICAL RESEARCH IN TOXICOLOGY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 10, no. 11, 1 November 1997 (1997-11-01), pages 1254-1258, XP000856548, ISSN: 0893-228X, DOI: DOI:10.1021/TX970102B
SIERZPUTOWSKA-GRACZ, H. ET AL.: "Chemistry and Structure of Modified Uridines in the Anticodon, Wobble Position of Transfer RNA are determined by Thiolation", J. AM. CHEM. SOC., vol. 109, 1987, XP002611975,
Attorney, Agent or Firm:
HUIZENGA, David, E. et al. (Arnall Golden Gregory LLP, 171 17th Street Nw, Suite 210, Atlanta GA, 30363-1031, US)
Download PDF: