Title:
NOVEL COMPOUNDS AND DERIVATIZATION OF DNAS AND RNAS ON THE NUCLEOBASES OF PYRIMIDINES FOR FUNCTION, STRUCTURE, AND THERAPEUTICS
Document Type and Number:
WIPO Patent Application WO/2010/135564
Kind Code:
A3
Abstract:
Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of counducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.
More Like This:
WO/2001/014399 | NOVEL A-500359 DERIVATIVES |
JPH0656672 | MEDICINAL COMPOSITION FOR MEDICAL TREATMENT OF AIRWAY DISORDER |
Inventors:
HUANG ZHEN (US)
HASSAN ABDALLA E A (US)
SHENG JIA (US)
ZHANG WEN (US)
HASSAN ABDALLA E A (US)
SHENG JIA (US)
ZHANG WEN (US)
Application Number:
PCT/US2010/035631
Publication Date:
May 05, 2011
Filing Date:
May 20, 2010
Export Citation:
Assignee:
SENA RES INC (US)
GEORGIA STATE UNIVERSITY OFFICE OF LEGAL AFFAIRS (US)
HUANG ZHEN (US)
HASSAN ABDALLA E A (US)
SHENG JIA (US)
ZHANG WEN (US)
GEORGIA STATE UNIVERSITY OFFICE OF LEGAL AFFAIRS (US)
HUANG ZHEN (US)
HASSAN ABDALLA E A (US)
SHENG JIA (US)
ZHANG WEN (US)
International Classes:
C07H19/06; C07H21/00
Domestic Patent References:
WO1992002258A1 | 1992-02-20 |
Foreign References:
DE2415812A1 | 1974-10-17 |
Other References:
THIVIYANATHAN, V. ET AL.: "Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 366, 15 August 2008 (2008-08-15), pages 752 - 757, XP002611974
FUJIMOTO J ET AL: "SYNTHESIS AND CLEAVAGE OF OLIGODEOXYNUCLEOTIDES CONTAINING A 5- HYDROXYURACIL RESIDUE AT A DEFINED SITE", CHEMICAL RESEARCH IN TOXICOLOGY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 10, no. 11, 1 November 1997 (1997-11-01), pages 1254 - 1258, XP000856548, ISSN: 0893-228X, DOI: DOI:10.1021/TX970102B
SIERZPUTOWSKA-GRACZ, H. ET AL.: "Chemistry and Structure of Modified Uridines in the Anticodon, Wobble Position of Transfer RNA are determined by Thiolation", J. AM. CHEM. SOC., vol. 109, 1987, XP002611975
FUJIMOTO J ET AL: "SYNTHESIS AND CLEAVAGE OF OLIGODEOXYNUCLEOTIDES CONTAINING A 5- HYDROXYURACIL RESIDUE AT A DEFINED SITE", CHEMICAL RESEARCH IN TOXICOLOGY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 10, no. 11, 1 November 1997 (1997-11-01), pages 1254 - 1258, XP000856548, ISSN: 0893-228X, DOI: DOI:10.1021/TX970102B
SIERZPUTOWSKA-GRACZ, H. ET AL.: "Chemistry and Structure of Modified Uridines in the Anticodon, Wobble Position of Transfer RNA are determined by Thiolation", J. AM. CHEM. SOC., vol. 109, 1987, XP002611975
Attorney, Agent or Firm:
HUIZENGA, David, E. et al. (171 17th Street Nw, Suite 210, Atlanta GA, US)
Download PDF: