Title:
NOVEL COMPOUNDS FOR SELECTIVE HISTONE DEACETYLASE INHIBITORS, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2014/178606
Kind Code:
A1
Abstract:
The present invention relates to novel urea derivatives and, more particularly, to novel urea derivatives with histone deacetylase (HDAC) inhibitory activity, isomers thereof, pharmaceutically acceptable salts thereof, their use for the preparation of a medicaments comprising the same, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing novel urea derivatives. The novel urea derivatives as selective histone deacetylase (HDAC) inhibitors are effective for the treatment of histone deacetylase-mediated diseases such as malignant tumors, inflammatory diseases, rheumatoid arthritis, neurodegeneration, etc.
Inventors:
LEE CHANGSIK (KR)
YANG HYUN-MO (KR)
CHOI HOJIN (KR)
KIM DOHOON (KR)
KIM SOYOUNG (KR)
HA NINA (KR)
LIM HYOJIN (KR)
KO EUNHEE (KR)
YOON SEONGAE (KR)
BAE DAEKWON (KR)
YANG HYUN-MO (KR)
CHOI HOJIN (KR)
KIM DOHOON (KR)
KIM SOYOUNG (KR)
HA NINA (KR)
LIM HYOJIN (KR)
KO EUNHEE (KR)
YOON SEONGAE (KR)
BAE DAEKWON (KR)
Application Number:
PCT/KR2014/003776
Publication Date:
November 06, 2014
Filing Date:
April 29, 2014
Export Citation:
Assignee:
CHONG KUN DANG PHARM CORP (KR)
International Classes:
C07D413/12; A61K31/5377; A61P29/00; A61P35/00
Domestic Patent References:
| WO2012106343A2 | 2012-08-09 | |||
| WO2002030879A2 | 2002-04-18 | |||
| WO2002022577A2 | 2002-03-21 | |||
| WO2004069823A1 | 2004-08-19 | |||
| WO2009026446A2 | 2009-02-26 | |||
| WO2003070691A1 | 2003-08-28 | |||
| WO2011106632A1 | 2011-09-01 | |||
| WO2007017728A2 | 2007-02-15 |
Foreign References:
| CN101230049A | 2008-07-30 | |||
| KR20100108220A | 2010-10-06 | |||
| US0771760A | 1904-10-04 | |||
| EP2305643A1 | 2011-04-06 |
Other References:
KATTAR, S. D. ET AL.: "Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI -1: 2) optimization.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 4, 15 February 2009 (2009-02-15), pages 1168 - 1172, XP025936065
STAHL; ELLIS, NATURE, vol. 403, 2000, pages 41 - 45
MARKS ET AL., NATURE CANCER REV, vol. 1, 2001, pages 189 - 202
INTERNATIONAL JOURNAL OF ONOCOLOGY, vol. 33, 2008, pages 637 - 646
MARKS, P.A, CURR OPIN ONCOL., vol. 13, 2001, pages 477 - 483
JOHNSTONE, R. W, NAT. REV. DRUG DISCOV., vol. 1, 2002, pages 287 - 299
CANCER RES, vol. 66, 2006, pages 5781 - 5789
MOL CANCER RES, vol. 5, 2007, pages 981
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
STAHL; ELLIS, NATURE, vol. 403, 2000, pages 41 - 45
MARKS ET AL., NATURE CANCER REV, vol. 1, 2001, pages 189 - 202
INTERNATIONAL JOURNAL OF ONOCOLOGY, vol. 33, 2008, pages 637 - 646
MARKS, P.A, CURR OPIN ONCOL., vol. 13, 2001, pages 477 - 483
JOHNSTONE, R. W, NAT. REV. DRUG DISCOV., vol. 1, 2002, pages 287 - 299
CANCER RES, vol. 66, 2006, pages 5781 - 5789
MOL CANCER RES, vol. 5, 2007, pages 981
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
Attorney, Agent or Firm:
AHN, So-Young (4th Fl. 344, Seocho-daero,Seocho-gu, Seoul 137-881, KR)
Download PDF:
Previous Patent: SMART HOME DEVICE AND NETWORK MANAGEMENT SYSTEM
Next Patent: IMAGE SENSOR AND METHOD FOR DRIVING SAME
Next Patent: IMAGE SENSOR AND METHOD FOR DRIVING SAME