Title:
NOVEL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO1994018326
Kind Code:
A3
Abstract:
DNA comprising a regulatory gene for clavulanic acid biosynthesis. DNA is no greater than 7 kb in length and has the configuration of restriction sites shown in FIG. 1 or a fragment thereof. Use of DNA in a method for producing clavulanic acid in a host.
Inventors:
WALTERS NICOLA JANE (GB)
BARTON BARRY (GB)
EARL ALISON JANE (GB)
BARTON BARRY (GB)
EARL ALISON JANE (GB)
Application Number:
PCT/GB1994/000173
Publication Date:
January 12, 1995
Filing Date:
January 28, 1994
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC (GB)
WALTERS NICOLA JANE (GB)
BARTON BARRY (GB)
EARL ALISON JANE (GB)
WALTERS NICOLA JANE (GB)
BARTON BARRY (GB)
EARL ALISON JANE (GB)
International Classes:
C07K14/36; C07K14/37; C12N1/21; C12N15/31; C12N15/09; C12P17/18; A61K38/00; (IPC1-7): C12N15/31; C12N15/63; C12P17/18; C07K13/00; C12N1/21
Foreign References:
| EP0349121A2 | 1990-01-03 | |||
| EP0354624A2 | 1990-02-14 |
Other References:
S. HORINOUCHI ET AL: "Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2)", GENE., vol. 95, 1990, AMSTERDAM NL, pages 49 - 56
CHEMICAL ABSTRACTS, vol. 117, no. 7, 17 August 1992, Columbus, Ohio, US; abstract no. 63796, J. MARTIN: "Cluster of genes for the biosynthesis of antibiotics: regulatory genes and overproduction of pharmaceuticals" page 197;
CHEMICAL ABSTRACTS, vol. 117, no. 7, 17 August 1992, Columbus, Ohio, US; abstract no. 63796, J. MARTIN: "Cluster of genes for the biosynthesis of antibiotics: regulatory genes and overproduction of pharmaceuticals" page 197;
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