Title:
NOVEL CRYSTAL OF 7-[2-(2-AMINOTHIAZOLE-4-YL)-2-HYDROXYIMINOACETAMIDO-3-VINYL-3-CEPHEM-4-CARBOXYLIC ACID (SYN ISOMER) AND METHOD FOR PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/085443
Kind Code:
A1
Abstract:
A novel crystal (B-type crystal) of 7-[2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetamide-3-vinyl-3-cephem-4-carboxylic acid (a syn isomer), characterized in that it exhibits peaks at diffraction angles shown in the following Table 1, in its powder X ray diffraction pattern; Table 1 Diffraction Angle 2Ѳ (°) approximately 11.7 approximately 16.1 approximately 18.6 approximately 21.2 approximately 22.3 approximately 24.4 approximately 26.2 and a method for preparing the novel crystal which comprises forming a crystal from a solution at a temperature of -5 to 5°C in an acidic state. The crystal is not bulky, exhibits good stability and good filterability, and is excellent in the solubility toward water, and thus can be prepared with ease.
Inventors:
IMAI EIJI (JP)
NIWA HIROYUKI (JP)
NIWA HIROYUKI (JP)
Application Number:
PCT/JP2004/003622
Publication Date:
October 07, 2004
Filing Date:
March 18, 2004
Export Citation:
Assignee:
SHIONO CHEMICAL CO LTD (JP)
IMAI EIJI (JP)
NIWA HIROYUKI (JP)
IMAI EIJI (JP)
NIWA HIROYUKI (JP)
International Classes:
C07D501/00; C07D501/22; (IPC1-7): C07D501/22
Domestic Patent References:
| WO2002098884A1 | 2002-12-12 | |||
| WO2004016623A1 | 2004-02-26 | |||
| WO2003050124A1 | 2003-06-19 |
Foreign References:
| JP2002145885A | 2002-05-22 | |||
| JPH01250384A | 1989-10-05 | |||
| JP2004035543A | 2004-02-05 |
Other References:
See also references of EP 1609793A4
Attorney, Agent or Firm:
Ono, Nobuo (1-13-1 Kandaizumi-cho, Chiyoda-k, Tokyo 24, JP)
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