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Title:
NOVEL CRYSTAL FORMS OF EPIRUBICIN HYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO/2011/118929
Kind Code:
A3
Abstract:
The present invention relates to the crystal form of Epirubicin hydrochloride stable against heat and water and the preparation method thereof. The novel crystal form has the physiochemical property stable against heat and water according to the present invention and it improves the excellent stability of the agents by preventing the relative substances from the one containing it. Furthermore, the crystal form of Epirubicin hydrochloride is suitable for mass production since it is easily prepared.

Inventors:
KIM, Moon-Sung (1 Hansolmaeul Cheonggu APT, Jeongja-dong Bundang-gu, Seongnam-si, Gyeonggi-do 463-010, 01-1601, KR)
KIM, Soon-Hoe (316-702, Cheongmyeong Maeul Dongsin Apt.956-2 Yeongtong-dong, Yeongtong-gu, Suwon-si, Gyeonggi-do 443-470, KR)
CHOI, Jun-Ho (1 Yedang Maeul Lotte Castle, Seoku-dong Hwaseong-si, Gyeonggi-do 445-170, 52-1402, KR)
SUNG, Si-Young (909-803, Sinjeong Maeul 9 DanjiPungdeokcheon-dong, Suji-gu, Yongin-si, Gyeonggi-do 448-170, KR)
LIM, Hong-Gyu (6 Humansia, Bora-dong Giheung-gu, Yongin-si, Gyeonggi-do 446-904, 01-1302, KR)
CHA, Dae-Won (5 Humansia, Bora-dong Giheung-gu, Yongin-si, Gyeonggi-do 446-904, 02-1003, KR)
SON, Byoung-Hwa (101-605, SeonbiMaeul Samjeong Apt.Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-953, KR)
RYU, Ki-Moon (8-507, Gyeongnam Apt.Banpo 2-dong, Seocho-gu, Seoul 137-042, KR)
Application Number:
KR2011/001706
Publication Date:
January 05, 2012
Filing Date:
March 11, 2011
Export Citation:
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Assignee:
DONG-A PHARM.CO.,LTD. (252Yongdu-dong, Dongdaemun-ku, Seoul 130-070, KR)
KIM, Moon-Sung (1 Hansolmaeul Cheonggu APT, Jeongja-dong Bundang-gu, Seongnam-si, Gyeonggi-do 463-010, 01-1601, KR)
KIM, Soon-Hoe (316-702, Cheongmyeong Maeul Dongsin Apt.956-2 Yeongtong-dong, Yeongtong-gu, Suwon-si, Gyeonggi-do 443-470, KR)
CHOI, Jun-Ho (1 Yedang Maeul Lotte Castle, Seoku-dong Hwaseong-si, Gyeonggi-do 445-170, 52-1402, KR)
SUNG, Si-Young (909-803, Sinjeong Maeul 9 DanjiPungdeokcheon-dong, Suji-gu, Yongin-si, Gyeonggi-do 448-170, KR)
LIM, Hong-Gyu (6 Humansia, Bora-dong Giheung-gu, Yongin-si, Gyeonggi-do 446-904, 01-1302, KR)
CHA, Dae-Won (5 Humansia, Bora-dong Giheung-gu, Yongin-si, Gyeonggi-do 446-904, 02-1003, KR)
SON, Byoung-Hwa (101-605, SeonbiMaeul Samjeong Apt.Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-953, KR)
RYU, Ki-Moon (8-507, Gyeongnam Apt.Banpo 2-dong, Seocho-gu, Seoul 137-042, KR)
International Classes:
C07H15/252; A61P35/00
Foreign References:
US20090099346A12009-04-16
US20060063726A12006-03-23
US5874550A1999-02-23
US4345068A1982-08-17
Attorney, Agent or Firm:
ROH, Jae-Chull (WAY with ROH Patent & Law Office, 4F. Halla Building, 641-17,Yeoksam-dong, Gangnam-gu, Seoul 135-909, KR)
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