Title:
A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3-(4-[2-(PIPERIDIN-1-YL)ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO2002034741
Kind Code:
A3
Abstract:
The present invention is directed to a novel, non-solvated, anhydrous crystal form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]-phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride and uses for same, including inhibition of disease states associated with estrogen deprivation including cardiovascular disease, hyperlipidemia, and osteoporosis; and inhibition of other pathological conditions such as endometriosis, uterine fibrosis, estrogen-dependent cancer (including breast and uterine cancer), prostate cancer, benign prostatic hyperplasia, CNS disorders including Alzheimer's disease, prevention of breast cancer, and up-regulating ChAT.
Inventors:
LUKE WAYNE DOUGLAS (US)
Application Number:
PCT/US2001/027773
Publication Date:
January 03, 2003
Filing Date:
October 18, 2001
Export Citation:
Assignee:
LILLY CO ELI (US)
LUKE WAYNE DOUGLAS (US)
LUKE WAYNE DOUGLAS (US)
International Classes:
A61K31/407; A61K31/445; A61K31/4535; A61K31/473; A61K31/565; A61K31/57; A61K47/20; A61P3/06; A61P9/00; A61P9/10; A61P13/08; A61P15/00; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C07D333/64; (IPC1-7): C07D333/64; A61K31/445; A61P35/00
Domestic Patent References:
| WO1998045287A1 | 1998-10-15 | |||
| WO2001009115A2 | 2001-02-08 | |||
| WO2001009116A2 | 2001-02-08 |
Foreign References:
| EP0729956A1 | 1996-09-04 |
Other References:
RABASSEDA ET AL: "Arzoxifene hydrochloride", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 24, no. 6, 1999, pages 599 - 604, XP002159973, ISSN: 0377-8282
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