Title:
NOVEL CRYSTALLINE FORMS OF 3-(4-AMINO-1-OXO-1,3 DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE
Document Type and Number:
WIPO Patent Application WO/2013/012485
Kind Code:
A3
Abstract:
The invention relates to novel crystalline forms of 3-(4-amino-l-oxo-l,3 dihydro- isoindol-2-yl)-piperidine-2,6-dione, including a novel urea cocrystal of 3-(4-amino-l-oxo-l,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione; a novel gallic acid cocrystal of 3-(4-amino-l-oxo- 1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione; a novel propyl gallate cocrystal of 3-(4-amino- l-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione; and a novel L- tartaric acid cocrystal of 3- (4- amino- 1-oxo- 1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione. The preparation and characterization of the novel crystalline forms according to various embodiments of the invention are described. The invention also relates to pharmaceutical compositions containing the novel crystalline forms, and the therapeutic use of the novel crystalline forms.
Inventors:
CHILDS SCOTT L (US)
LINGIREDDY SHREENIVAS R (US)
BARISHANSKY NATHAN (US)
LINGIREDDY SHREENIVAS R (US)
BARISHANSKY NATHAN (US)
Application Number:
PCT/US2012/041186
Publication Date:
April 25, 2013
Filing Date:
June 07, 2012
Export Citation:
Assignee:
AMPLIO PHARMA LLC (US)
CHILDS SCOTT L (US)
LINGIREDDY SHREENIVAS R (US)
BARISHANSKY NATHAN (US)
CHILDS SCOTT L (US)
LINGIREDDY SHREENIVAS R (US)
BARISHANSKY NATHAN (US)
International Classes:
C07D401/04; A61K31/4439; A61P17/00; A61P29/00
Domestic Patent References:
| WO2010100476A2 | 2010-09-10 | |||
| WO2006028964A1 | 2006-03-16 | |||
| WO2010054833A1 | 2010-05-20 |
Foreign References:
| US20110065750A1 | 2011-03-17 |
Attorney, Agent or Firm:
Michelle E. O'Brien (PLLC1951 Kidwell Drive,Suite 74, Vienna Virginia, US)
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