Title:
NOVEL CYCLIC TETRAPEPTIDE DERIVATIVES AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1999/011659
Kind Code:
A1
Abstract:
Cyclic tetrapeptide derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, cyclic tetrapeptide compounds analogous thereto, and histone deacetylase inhibitors, MHC class-1 molecule expression promoters and medicinal compositions containing these cyclic tetrapeptide derivatives as the active ingredient: wherein R¿11?, R¿12?, R¿21? and R¿22? represent each hydrogen or a monovalent group selected from linear or branched C¿1-6? alkyl, benzyl, 4-methoxybenzyl, 3-indolylmethyl, (N-methoxy-3-indolyl)methyl, (N-formyl-3-indolyl)methyl, etc.; R¿3? represents a divalent group selected from divalent linear C¿3-4? hydrocarbyl optionally having a branched chain added thereto or optionally substituted by a heteroatom; and R¿4? represents a divalent group derived from divalent linear C¿4-6? hydrocarbyl optionally having a branched chain added thereto.
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Inventors:
NISHINO NORIKAZU (JP)
YOSHIDA MINORU (JP)
HORINOUCHI SUEHARU (JP)
KOMATSU YASUHIKO (JP)
MIMOTO TSUTOMU (JP)
YOSHIDA MINORU (JP)
HORINOUCHI SUEHARU (JP)
KOMATSU YASUHIKO (JP)
MIMOTO TSUTOMU (JP)
Application Number:
PCT/JP1998/003893
Publication Date:
March 11, 1999
Filing Date:
September 01, 1998
Export Citation:
Assignee:
JAPAN ENERGY CORP (JP)
NISHINO NORIKAZU (JP)
YOSHIDA MINORU (JP)
HORINOUCHI SUEHARU (JP)
KOMATSU YASUHIKO (JP)
MIMOTO TSUTOMU (JP)
NISHINO NORIKAZU (JP)
YOSHIDA MINORU (JP)
HORINOUCHI SUEHARU (JP)
KOMATSU YASUHIKO (JP)
MIMOTO TSUTOMU (JP)
International Classes:
C07K5/12; A61K38/00; (IPC1-7): C07K5/12; A61K38/12
Other References:
KIJIMA M., ET AL.: "TRAPOXIN, AN ANTITUMOR CYCLIC TETRAPEPTIDE, IS AN IRREVERSIBLE INHIBITOR OF MAMMALIAN HISTONE DEACETYLASE.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 268., no. 30., 1 January 1993 (1993-01-01), US, pages 22429 - 22435., XP002914497, ISSN: 0021-9258
BERNARDI E., ET AL.: "ANTITUMORAL CYCLIC PEPTIDE ANALOGUES OF CHLAMYDOCIN.", PEPTIDES, ELSEVIER, AMSTERDAM, NL, vol. 14., no. 06., 1 January 1993 (1993-01-01), AMSTERDAM, NL, pages 1091 - 1093., XP002914496, ISSN: 0196-9781, DOI: 10.1016/0196-9781(93)90160-I
See also references of EP 1010705A4
BERNARDI E., ET AL.: "ANTITUMORAL CYCLIC PEPTIDE ANALOGUES OF CHLAMYDOCIN.", PEPTIDES, ELSEVIER, AMSTERDAM, NL, vol. 14., no. 06., 1 January 1993 (1993-01-01), AMSTERDAM, NL, pages 1091 - 1093., XP002914496, ISSN: 0196-9781, DOI: 10.1016/0196-9781(93)90160-I
See also references of EP 1010705A4
Attorney, Agent or Firm:
Hiraki, Yusuke (3rd Floor 17-1, Toranomon 1-chome Minato-ku Tokyo, JP)
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