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Title:
NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2018/186366
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel cyclin-dependent kinase 8 and/or 19 inhibitor that is useful as an anticancer agent. The present invention relates to a cyclin-dependent kinase 8 and/or 19 inhibitor that contains, as an active component, a compound expressed by general formula (I) (the definition of each symbol therein being as indicated in the specification) or a pharmaceutically acceptable salt thereof. The present invention also relates to a use of said inhibitor as a cancer preventative and/or therapeutic agent.

Inventors:
KITAO TATSUYA (JP)
TAKEDA SHIGEMITSU (JP)
SHOJI YOSHIMICHI (JP)
SHIRAHASE HIROAKI (JP)
Application Number:
PCT/JP2018/014163
Publication Date:
October 11, 2018
Filing Date:
April 02, 2018
Export Citation:
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Assignee:
KYOTO PHARMA IND (JP)
International Classes:
A61K31/166; A61K31/341; A61K31/351; A61K31/357; A61K31/382; A61K31/397; A61K31/4427; A61K31/443; A61K31/445; A61K31/4545; A61K31/495; A61K31/496; A61K31/5375; A61K31/5377; A61K45/00; A61P1/04; A61P1/16; A61P1/18; A61P5/00; A61P11/00; A61P13/08; A61P13/10; A61P15/00; A61P17/00; A61P25/00; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
WO2015030189A12015-03-05
WO2015159938A12015-10-22
WO2015159937A12015-10-22
WO2007133772A22007-11-22
WO2013116786A12013-08-08
WO2014072435A12014-05-15
WO2015159937A12015-10-22
WO2015159938A12015-10-22
WO2015030189A12015-03-05
Foreign References:
JP2015506376A2015-03-02
JP2016503408A2016-02-04
US20120071477A12012-03-22
JP2017073969A2017-04-13
Other References:
A. D. CLARK ET AL., CRIT REV BIOCHEM MOL BIOL., vol. 50, no. 5, 2015, pages 393 - 426
R. FIRESTEIN ET AL., NATURE, vol. 455, 2008, pages 547 - 551
H. E. PELISH ET AL., NATURE, vol. 526, 2015, pages 273 - 276
T. RZYMSKI ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 1845, 2015, pages 1617 - 1629
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Development of Pharmaceutical Product", vol. 7, 1990, HIROKAWA-SHOTEN LTD., pages: 163 - 198
See also references of EP 3607944A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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