NOVEL CYP17 INHIBITORS

WIPO Patent Application WO/2011/088160

A3

Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.

JPS5318542	NOVEL RING REDUCTION METHOD OF CYCLIC COMPOUND
WO/2013/101719	AMOORANIN COMPOUNDS AND ANALOGS THEREOF AND RELATED METHODS OF USE
JP2006528652	Steroid derivatives and their medicinal use.

CHU DANIEL (US)
WANG BING (US)
YE TAO (CN)

PCT/US2011/021043

October 13, 2011

January 13, 2011

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BIOMARIN PHARM INC (US)
CHU DANIEL (US)
WANG BING (US)
YE TAO (CN)

C07J61/00; A61P5/28; C07D487/04; C07J73/00

WO1993020097A1	1993-10-14
WO1997030069A1	1997-08-21
WO2010062506A2	2010-06-03

US5965548A

1999-10-12

POTTER G A ET AL: "Novel steroidal inhibitors of human cytochrome P450-17alpha (17-alpha-hydroxylase-C-17,20-lyase): Potential agents for the treatment of prostatic cancer", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 38, no. 13, 1 January 1995 (1995-01-01), pages 2463 - 2471, XP002302489, ISSN: 0022-2623, DOI: 10.1021/JM00013A022
PERRON S ET AL: "Effects of 4-MA, a potent inhibitor of 5alpha-reductase, on 3beta-hydroxysteroid dehydrogenase/DELTA<5>-DELTA<4>-isomerase activity in guinea pig adrenals", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 59, no. 6, 1 June 1994 (1994-06-01), pages 371 - 376, XP025206220, ISSN: 0039-128X, [retrieved on 19940601], DOI: 10.1016/0039-128X(94)90004-3

DANEK, Shelley, C. et al. (GERSTEIN & BORUN LLP233 S. Wacker Drive, 6300 Willis Towe, Chicago IL, US)

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