NOVEL DIAMIDE DERIVATIVE

WIPO Patent Application WO/2008/123017

A1

Disclosed is a novel compound having a strong FXa inhibitory activity and exhibits quick, sufficient and lasting antithrombotic effect even by oral administration. Specifically disclosed is a compound represented by the general formula (I) below, a pharmacologically acceptable salt thereof or an FXa inhibitor containing any of them as an active ingredient. (In the formula, ring A represents a benzene ring; R1 represents a hydrogen atom, a halogeno group or the like; R2 represents a carboxy group, a carbamoyl group or the like; T1 represents a -C(=O)NH- group or the like; T2 represents a -CH2-CH2-C(=O)NH- group or the like; Q1 represents a tetrahydronaphthyridinyl group, a tetrahydrothiazolopyridyl group or the like; Q2 represents a single bond; and Q3 represents a phenyl group, a pyridyl group or the like.)

MOCHIZUKI AKIYOSHI (JP)
NAGATA TSUTOMU (JP)
KANNO HIDEYUKI (JP)

PCT/JP2008/000506

October 16, 2008

March 10, 2008

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DAIICHI SANKYO CO LTD (JP)
MOCHIZUKI AKIYOSHI (JP)
NAGATA TSUTOMU (JP)
KANNO HIDEYUKI (JP)

C07D211/62; A61K31/167; A61K31/381; A61K31/427; A61K31/429; A61K31/437; A61K31/4375; A61K31/444; A61K31/445; A61K31/4535; A61K31/454; A61K31/4545; A61K31/496; A61K31/497; A61K31/501; A61K31/502; A61K31/506; A61K31/5375; A61K31/5377; A61K31/55; A61P7/02; A61P9/10; A61P11/00; A61P29/00; C07D265/32; C07D401/12; C07D409/12; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D513/04

WO2001074791A1	2001-10-11
WO1998046569A1	1998-10-22

JP2004203791A

2004-07-22

THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (3-6Nihonbashiningyocho,1-chome, Chuo-ku, Tokyo 13, JP)

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