Title:
NOVEL DIHYDRO-QUINAZOLINONE COMPOUND OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF, AND CELL GROWTH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/131798
Kind Code:
A1
Abstract:
Provided is a cell growth inhibitor containing, as an active ingredient, a compound represented by general formula (1) below, or a pharmacologically acceptable salt thereof. [In general formula (1), J1 and J2 represent CH or N, but both cannot simultaneously represent CH; r represents 0-4; R101 represents a C1-6 alkyl group optionally substituted with a halogen atom, and may be the same or different if r is two or more; s represents 0-5; R102 represents a halogen atom or the like, which may be the same or different if s is two or more; R103 represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkyl C1-6 alkyl group; if R101 is in the 8th position, said R101 and R103 may integrate to form a heterocycle having a 5- to 7-membered ring.]
Inventors:
YOSHIDA MINORU (JP)
SEIMIYA HIROYUKI (JP)
YASHIRODA YOKO (JP)
WASHIZUKA KENICHI (JP)
SHIRAI FUMIYUKI (JP)
YOSHIMOTO NOBUKO (JP)
KAZAMI JUNICHI (JP)
SEIMIYA HIROYUKI (JP)
YASHIRODA YOKO (JP)
WASHIZUKA KENICHI (JP)
SHIRAI FUMIYUKI (JP)
YOSHIMOTO NOBUKO (JP)
KAZAMI JUNICHI (JP)
Application Number:
PCT/JP2018/047944
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
Assignee:
RIKEN (JP)
JAPANESE FOUND FOR CANCER RES (JP)
YAKULT HONSHA KK (JP)
JAPANESE FOUND FOR CANCER RES (JP)
YAKULT HONSHA KK (JP)
International Classes:
A61K31/517; A61K31/519; A61K31/5377; A61K31/5383; A61P11/00; A61P21/02; A61P25/00; A61P31/12; A61P31/22; A61P35/00; A61P43/00; C07D401/14; C07D403/04; C07D471/04; C07D487/06; C07D498/06
Domestic Patent References:
| WO2010056758A1 | 2010-05-20 | |||
| WO2013117288A1 | 2013-08-15 | |||
| WO2013182580A1 | 2013-12-12 | |||
| WO2012076898A1 | 2012-06-14 |
Foreign References:
| JP2004515544A | 2004-05-27 | |||
| JP2009513504A | 2009-04-02 | |||
| JP2015535831A | 2015-12-17 |
Other References:
JOHANNES, J. W. ET AL.: "Pyrimidinone nicotinamide mimetics as selective tankyrase and Wnt pathway inhibitors suitable for in vivo pharmacology", ACS MED CHEM LETT, vol. 6, no. 3, 2015, pages 254 - 259, XP055417166, DOI: 10.1021/ml5003663
HAIKARAINEN, T. ET AL.: "Para-substituted 2-phenyl- 3, 4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors", CHEMMEDCHEM, vol. 8, no. 12, 2013, pages 1978 - 1985, XP055146273, DOI: 10.1002/cmdc.201300337
DATABASE CAS 8 October 2018 (2018-10-08), retrieved from STN Database accession no. 1252133-21-3
DATABASE CAS 7 February 2018 (2018-02-07), retrieved from STN Database accession no. 1223730-46-8
HUANG SM. ET AL., NATURE, vol. 461, 2009, pages 614 - 620
MICHAEL D. SHULTZ ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 2013, pages 3012 - 3023
SYNTHESIS, vol. 10, 1998, pages 1140
TETRAHEDRON LETTERS, vol. 42, 2001, pages 9117
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, pages 184932
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1252133-21-3
See also references of EP 3733186A4
HAIKARAINEN, T. ET AL.: "Para-substituted 2-phenyl- 3, 4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors", CHEMMEDCHEM, vol. 8, no. 12, 2013, pages 1978 - 1985, XP055146273, DOI: 10.1002/cmdc.201300337
DATABASE CAS 8 October 2018 (2018-10-08), retrieved from STN Database accession no. 1252133-21-3
DATABASE CAS 7 February 2018 (2018-02-07), retrieved from STN Database accession no. 1223730-46-8
HUANG SM. ET AL., NATURE, vol. 461, 2009, pages 614 - 620
MICHAEL D. SHULTZ ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 2013, pages 3012 - 3023
SYNTHESIS, vol. 10, 1998, pages 1140
TETRAHEDRON LETTERS, vol. 42, 2001, pages 9117
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, pages 184932
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1252133-21-3
See also references of EP 3733186A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Download PDF: