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Title:
NOVEL DIHYDRO-QUINAZOLINONE COMPOUND OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF, AND CELL GROWTH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/131798
Kind Code:
A1
Abstract:
Provided is a cell growth inhibitor containing, as an active ingredient, a compound represented by general formula (1) below, or a pharmacologically acceptable salt thereof. [In general formula (1), J1 and J2 represent CH or N, but both cannot simultaneously represent CH; r represents 0-4; R101 represents a C1-6 alkyl group optionally substituted with a halogen atom, and may be the same or different if r is two or more; s represents 0-5; R102 represents a halogen atom or the like, which may be the same or different if s is two or more; R103 represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkyl C1-6 alkyl group; if R101 is in the 8th position, said R101 and R103 may integrate to form a heterocycle having a 5- to 7-membered ring.]

Inventors:
YOSHIDA Minoru (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
SEIMIYA Hiroyuki (3-8-31 Ariake Koto-k, Tokyo 50, 〒1358550, JP)
YASHIRODA Yoko (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
WASHIZUKA Kenichi (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
SHIRAI Fumiyuki (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
YOSHIMOTO Nobuko (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
KAZAMI Junichi (2-1 Hirosawa, Wako-sh, Saitama 98, 〒3510198, JP)
Application Number:
JP2018/047944
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
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Assignee:
RIKEN (2-1 Hirosawa, Wako-shi Saitama, 98, 〒3510198, JP)
JAPANESE FOUNDATION FOR CANCER RESEARCH (3-8-31 Ariake, Koto-ku Tokyo, 50, 〒1358550, JP)
KABUSHIKI KAISHA YAKULT HONSHA (1-19, Higashi-Shinbashi 1-chome Minato-k, Tokyo 60, 〒1058660, JP)
International Classes:
A61K31/517; A61K31/519; A61K31/5377; A61K31/5383; A61P11/00; A61P21/02; A61P25/00; A61P31/12; A61P31/22; A61P35/00; A61P43/00; C07D401/14; C07D403/04; C07D471/04; C07D487/06; C07D498/06
Domestic Patent References:
WO2010056758A12010-05-20
Foreign References:
JP2004515544A2004-05-27
JP2009513504A2009-04-02
JP2015535831A2015-12-17
Other References:
JOHANNES, J. W. ET AL.: "Pyrimidinone nicotinamide mimetics as selective tankyrase and Wnt pathway inhibitors suitable for in vivo pharmacology", ACS MED CHEM LETT, vol. 6, no. 3, 2015, pages 254 - 259, XP055417166, DOI: 10.1021/ml5003663
HAIKARAINEN, T. ET AL.: "Para-substituted 2-phenyl- 3, 4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors", CHEMMEDCHEM, vol. 8, no. 12, 2013, pages 1978 - 1985, XP055146273, DOI: 10.1002/cmdc.201300337
DATABASE CAS 8 October 2018 (2018-10-08), retrieved from STN Database accession no. 1252133-21-3
DATABASE CAS 7 February 2018 (2018-02-07), retrieved from STN Database accession no. 1223730-46-8
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (Kikuya Bldg. 9th Floor, 2-8-21 Kyobashi, Chuo-k, Tokyo 31, 〒1040031, JP)
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