NOVEL DISACCHARIDE DERIVATIVE

Title:

NOVEL DISACCHARIDE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1995/007285

Kind Code:

A1

Abstract:

A novel disaccharide derivative represented by chemical formula (I), stereochemical isomers and salts thereof, and a pharmaceutical composition containing the same as the active ingredient. The compound has various biological activities such as potent mitogenic activity, adjuvant activity, polyclonal B-cell activating (nonspecific protective) activity, natural killer activity, antitumor activity and antiviral activity, but scarcely has the activity of inducing the production of so-called inflammatory cytokines, such as tumor necrotizing factor (TNF) and IL-1, from macrophages unlike the lipid A and derivatives thereof. Therefore, it is free from noxious effects in which the lipid A and derivatives thereof have been problematic, such as lethal toxicity and pyrogenicity, and hence it is useful not only as immunopotentiator, antitumor agent and antiviral agent, but also as a therapeutic or preventive agent for sepsis, rheumatoid arthritis, and so forth.

Inventors:

KODAMA TOHRU (JP)
SAITOH MASAYUKI (JP)
OGAWA TOMOHIKO (JP)

Application Number:

PCT/JP1994/000376

Publication Date:

March 16, 1995

Filing Date:

March 09, 1994

Export Citation:

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Assignee:

SUNTORY LTD (JP)
KODAMA TOHRU (JP)
SAITOH MASAYUKI (JP)
OGAWA TOMOHIKO (JP)

International Classes:

C07H3/04; C07H13/04; C07H13/06; C12P19/26; (IPC1-7): C07H11/04; A61K31/715; C12P19/26

Foreign References:

JPS5948497A	1984-03-19
JPS61227586A	1986-10-09

Other References: