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Title:
NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2015/163427
Kind Code:
A1
Abstract:
The present invention provides: a novel disubstituted 1, 2, 4-triazine compound that has an aldosterone synthase inhibitory activity and is useful in the prevention and/or treatment of various diseases or symptoms involving aldosterone, or a pharmaceutically acceptable salt of said compound; a method for producing same; a use for same; and a pharmaceutical composition, etc. formed using the compound or pharmaceutically acceptable salt thereof as an active ingredient. Provided is a compound represented by general formula [I]: [In the formula, RA is a group, etc. represented by formula (A-1) (in the formula, ring A1 is an optionally substituted cycloalkyl group, etc.), and RB is a monocyclic cycloalkyl group, etc.], or a pharmaceutically acceptable salt of said compound.

Inventors:
USHIROGOCHI HIDEKI (JP)
SASAKI WATARU (JP)
ONDA YUICHI (JP)
SAKAKIBARA RYO (JP)
AKAHOSHI FUMIHIKO (JP)
Application Number:
PCT/JP2015/062440
Publication Date:
October 29, 2015
Filing Date:
April 23, 2015
Export Citation:
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Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
C07D253/06; A61K31/53; A61K31/5377; A61K31/541; A61K31/553; A61P1/16; A61P3/04; A61P3/12; A61P5/38; A61P5/42; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P35/00; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D413/12; C07D413/14; C07D417/04; C07D453/02; C07D471/04; C07D471/08; C07D498/08; C07D498/10
Domestic Patent References:
WO2013079452A12013-06-06
WO2013037779A12013-03-21
WO2012012478A12012-01-26
WO2010130796A12010-11-18
WO2009156462A22009-12-30
WO2010130796A12010-11-18
WO2012012478A12012-01-26
WO2002030891A12002-04-18
Foreign References:
US20100292225A12010-11-18
Other References:
HAKKI,T. ET AL.: "The development of a whole- cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 125, no. 1-2, 2011, pages 120 - 128, XP028385075
"database", Database accession no. 1060824-77-2
NEW ENGLAND JOURNAL OF MEDICINE, vol. 341, 1999, pages 709 - 717
NEW ENGLAND JOURNAL OF MEDICINE, vol. 348, 2003, pages 1309 - 1321
CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 313, 2013, pages 1385 - 1401
CURRENT HYPERTENSION REPORTS, vol. 15, 2013, pages 484 - 488
T. HAKKI ET AL., J. STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY, vol. 125, 2011, pages 120 - 128
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 5408
CHABRE ET AL., JCE & M, vol. 85, no. 11, 2000, pages 4060 - 68
See also references of EP 3135668A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
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