Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL DISUBSTITUTED ADAMANTYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITION FOR SUPPRESSING CANCER METASTASIS COMPRISING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2014/084494
Kind Code:
A1
Abstract:
The present invention relates to a novel disubstituted adamantyl derivative or a pharmaceutically acceptable salt thereof, to a production method for same, and to a pharmaceutical composition for suppressing cancer metastasis or combating cancer comprising same as an active ingredient. The disubstituted adamantyl derivative according to the present invention suppresses the HIF-1 enzyme, which is associated with cancer metastasis, and so effects dose-dependent inhibition of the production of TWIST proteins, which are proteins associated with cancer metastasis, and thereby suppresses the consequent activities of beta-catenin and Rho proteins (RhoA), which are proteins associated with subsequent cancer metastasis, and of MMP2 and MMP9 which are genes associated with EMT, and as a result the derivative has an outstanding effect in inhibiting cancer cell metastasis and, in addition, the derivative is not cytotoxic and so has no cytotoxic side effects even when absorbed into the human body, and can therefore advantageously be used as a pharmaceutical composition for suppressing cancer metastasis or combating cancer.

Inventors:
WON MI SUN (KR)
LEE KYEONG (KR)
KIM BO KYUNG (KR)
BAN HYUN SEUNG (KR)
SON SEOHYUN (KR)
CHUNG KYUNG-SOOK (KR)
Application Number:
PCT/KR2013/009119
Publication Date:
June 05, 2014
Filing Date:
October 11, 2013
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
UNIV DONGGUK IND ACAD COOP (KR)
International Classes:
C07C235/24; A61K31/166; A61P35/00
Domestic Patent References:
WO2011014009A22011-02-03
WO2010059618A12010-05-27
WO2006024627A22006-03-09
Foreign References:
US6462064B12002-10-08
US20050010052A12005-01-13
US20110178086A12011-07-21
Attorney, Agent or Firm:
LEE, Won Hee (Sung-ji Heights II642-16 Yoksam-dong,Kangnam-ku, Seoul 135-080, KR)
Download PDF: