Title:
NOVEL DNA-RNA HYBRID REGULAR TETRAHEDRON STRUCTURE OR RNA TETRAHEDRON STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2016/140492
Kind Code:
A1
Abstract:
The present invention relates to a novel DNA-RNA hybrid regular tetrahedron structure or RNA tetrahedron structure which can be used in expression inhibition of a target gene or in drug delivery and, more specifically, to a DNA-RNA hybrid regular tetrahedron structure or RNA tetrahedron structure comprising small interfering RNA (siRNA) or microRNA (miRNA) sequences of a target gene. The present invention provides a functional RNA nanostructure in which siRNA or miRNA is introduced, wherein the structure is delivered into a cell through self-delivery at a high efficiency, and can give rise to RNA interference mechanism to induce apoptosis of a target cell. In addition, the present invention can provide a controllable structure in which a drug is released to the outside by supporting the drug in pores. Also, an RNA nanostructure leading to apoptosis of a target cell can be prepared by using RNA interference with the technology of the present invention as the original technology, whereby the RNA nanostructure is expected to be commercialized as a new drug.
Inventors:
LEE DONGKI (KR)
KANG SI NAE (KR)
KANG SI NAE (KR)
Application Number:
PCT/KR2016/002048
Publication Date:
September 09, 2016
Filing Date:
March 02, 2016
Export Citation:
Assignee:
UNIV SUNGKYUNKWAN RES & BUS (KR)
International Classes:
C12N15/113; A61K47/06; C12N15/10
Foreign References:
| US20090227774A1 | 2009-09-10 | |||
| US20100323018A1 | 2010-12-23 |
Other References:
LEE, HYUKJIN ET AL.: "Molecularly Self-assembled Nucleic Acid Nanoparticles for Targeted in Vivo siRNA Delivery", NATURE NANOTECHNOLOGY, vol. 7, no. 6, 2012, pages 389 - 393, XP002752154, DOI: doi:10.1038/nnano.2012.73
KO, SEUNG HYEON ET AL.: "Synergistic Self-assembly of RNA and DNA Molecules", NATURE CHEMISTRY, vol. 2, no. 12, 2010, pages 1050 - 1055
GOODMAN, RUSSE LL P. ET AL.: "The Single-step Synthesis of a DNA Tetrahedron", CHEMICAL COMMUNICATIONS, vol. 12, 2004, pages 1372 - 1373
KO, SEUNG HYEON ET AL.: "Synergistic Self-assembly of RNA and DNA Molecules", NATURE CHEMISTRY, vol. 2, no. 12, 2010, pages 1050 - 1055
GOODMAN, RUSSE LL P. ET AL.: "The Single-step Synthesis of a DNA Tetrahedron", CHEMICAL COMMUNICATIONS, vol. 12, 2004, pages 1372 - 1373
Attorney, Agent or Firm:
LEE, MYOUNG-JIN (KR)
이명진 (KR)
이명진 (KR)
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