Title:
NOVEL DUAL-TARGETED PROTEIN SPECIFICALLY BINDING TO DLL4 AND VEGF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/005632
Kind Code:
A1
Abstract:
The present invention relates to a dual-targeted protein comprising: a novel protein specifically binding to delta like ligand 4 (DLL4); and an antibody specifically binding to a vascular endothelial cell growth factor (VEGF).
Inventors:
LEE DONG HEON (KR)
MOON KYUNG DUK (KR)
CHOI YU BIN (KR)
KANG KYUNG JAE (KR)
KIM DONG IN (KR)
AHN JIN HYUNG (KR)
YOU WEON KYOO (KR)
JUNG JINWON (KR)
MOON KYUNG DUK (KR)
CHOI YU BIN (KR)
KANG KYUNG JAE (KR)
KIM DONG IN (KR)
AHN JIN HYUNG (KR)
YOU WEON KYOO (KR)
JUNG JINWON (KR)
Application Number:
PCT/KR2014/006090
Publication Date:
January 15, 2015
Filing Date:
July 08, 2014
Export Citation:
Assignee:
HANWHA CHEMICAL CORP (KR)
International Classes:
C07K16/46; C07K19/00; C12N15/62; G01N33/574
Foreign References:
| US20110123532A1 | 2011-05-26 | |||
| KR20110014607A | 2011-02-11 | |||
| KR20090088936A | 2009-08-20 | |||
| KR20110055726A | 2011-05-25 | |||
| US20110189200A1 | 2011-08-04 |
Other References:
BOWDEN, E. T. ET AL.: "DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.", CANCER RES., vol. 71, no. 18, 29 July 2011 (2011-07-29), pages 6073 - 6083, XP055221882
YAN, M. ET AL.: "Delta-like 4/Notch signaling and its therapeutic implications. Clin.", CANCER RES., vol. 13, no. 24, 15 December 2007 (2007-12-15), pages 7243 - 7246, XP002563705
YAN, M. ET AL.: "Delta-like 4/Notch signaling and its therapeutic implications. Clin.", CANCER RES., vol. 13, no. 24, 15 December 2007 (2007-12-15), pages 7243 - 7246, XP002563705
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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