Title:
NOVEL ENCOCHLEATION METHODS, COCHLEATES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2004091578
Kind Code:
A3
Abstract:
Disclose are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
Inventors:
MANNINO RAPHAEL J (US)
GOULD-FOGERITE SUSAN (US)
KRAUSE-ELSMORE SARA L (US)
DELMARRE DAVID (US)
LU RUYING (US)
GOULD-FOGERITE SUSAN (US)
KRAUSE-ELSMORE SARA L (US)
DELMARRE DAVID (US)
LU RUYING (US)
Application Number:
PCT/US2004/011026
Publication Date:
March 31, 2005
Filing Date:
April 09, 2004
Export Citation:
Assignee:
BIODELIVERY SCIENCES INTERNATI (US)
UNIV NEW JERSEY MED (US)
MANNINO RAPHAEL J (US)
GOULD-FOGERITE SUSAN (US)
KRAUSE-ELSMORE SARA L (US)
DELMARRE DAVID (US)
LU RUYING (US)
UNIV NEW JERSEY MED (US)
MANNINO RAPHAEL J (US)
GOULD-FOGERITE SUSAN (US)
KRAUSE-ELSMORE SARA L (US)
DELMARRE DAVID (US)
LU RUYING (US)
International Classes:
A61K9/127; A61K31/00; A61K31/7048; (IPC1-7): A61K9/127
Domestic Patent References:
| WO2001052817A2 | 2001-07-26 |
Foreign References:
| US5994318A | 1999-11-30 |
Other References:
ZARIF L ET AL: "COCHLEATES: NEW LIPID-BASED DRUG DELIVERY SYSTEM", JOURNAL OF LIPOSOME RESEARCH, MARCEL DEKKER, NEW YORK, US, vol. 10, no. 4, November 2000 (2000-11-01), pages 523 - 538, XP000977999, ISSN: 0898-2104
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