NOVEL ENCOCHLEATION METHODS, COCHLEATES AND METHODS OF USE

Title:

NOVEL ENCOCHLEATION METHODS, COCHLEATES AND METHODS OF USE

Document Type and Number:

WIPO Patent Application WO2004091578

Kind Code:

A8

Abstract:

Disclose are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.

Inventors:

MANNINO RAPHAEL J (US)
GOULD-FOGERITE SUSAN (US)
KRAUSE-ELSMORE SARA L (US)
DELMARRE DAVID (US)
LU RUYING (US)

Application Number:

PCT/US2004/011026

Publication Date:

January 27, 2005

Filing Date:

April 09, 2004

Export Citation:

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Assignee:

BIODELIVERY SCIENCES INTERNATI (US)
UNIV NEW JERSEY MED (US)
MANNINO RAPHAEL J (US)
GOULD-FOGERITE SUSAN (US)
KRAUSE-ELSMORE SARA L (US)
DELMARRE DAVID (US)
LU RUYING (US)

International Classes:

A61K9/127; A61K31/00; A61K31/7048; (IPC1-7): A61K9/127

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