Title:
NOVEL ENDOTHELIALLY EXPRESSED DNAS AND PROTEINS, AND THEIR USE
Document Type and Number:
WIPO Patent Application WO2003001863
Kind Code:
A3
Abstract:
The present invention relates to novel, specifically expressed proteins and to nucleic acid sequences or transgenic nucleic acids constructs which encode the proteins. The invention also relates to transgenic organisms or animals which harbor the nucleic acid sequences or recombinant nucleic acid constructs and also to monoclonal or polyclonal antibodies and binding factors which are directed against the isolated proteins. The invention furthermore relates to a process for finding substances which possess specific finding affinity with the proteins according to the invention, and to a process for qualitatively or quantitatively detecting the nucleic acid sequences according to the invention or the proteins according to the invention. The invention furthermore relates to the use of nucleic acid sequences and proteins. The invention also encompasses processes for finding substances which modulate the function of the proteins according to the invention. It also relates to the use of these proteins for producing drugs.
Inventors:
SCHEEK SIGRID (DE)
HIEMISCH HOLGER (DE)
LANAHAN ANTHONY (US)
REGARD JEAN B (US)
WORLEY PAUL F (US)
KRUPP ECKART (DE)
SCHWANINGER MARKUS (DE)
FARADAY NAUDER (US)
HIEMISCH HOLGER (DE)
LANAHAN ANTHONY (US)
REGARD JEAN B (US)
WORLEY PAUL F (US)
KRUPP ECKART (DE)
SCHWANINGER MARKUS (DE)
FARADAY NAUDER (US)
Application Number:
PCT/EP2002/006770
Publication Date:
July 31, 2003
Filing Date:
June 19, 2002
Export Citation:
Assignee:
AXARON BIOSCIENCE AG (DE)
SCHEEK SIGRID (DE)
HIEMISCH HOLGER (DE)
LANAHAN ANTHONY (US)
REGARD JEAN B (US)
WORLEY PAUL F (US)
KRUPP ECKART (DE)
SCHWANINGER MARKUS (DE)
FARADAY NAUDER (US)
SCHEEK SIGRID (DE)
HIEMISCH HOLGER (DE)
LANAHAN ANTHONY (US)
REGARD JEAN B (US)
WORLEY PAUL F (US)
KRUPP ECKART (DE)
SCHWANINGER MARKUS (DE)
FARADAY NAUDER (US)
International Classes:
A61K49/00; C07K14/47; C12N15/12; (IPC1-7): C12N15/12; A01K67/027; A61K38/17; A61K48/00; C12N15/11; C12N15/62; C12Q1/68; G01N33/50; G01N33/53
Domestic Patent References:
| WO1999040225A1 | 1999-08-12 | |||
| WO2000076309A2 | 2000-12-21 | |||
| WO1999018191A1 | 1999-04-15 | |||
| WO1997038082A2 | 1997-10-16 |
Other References:
DATABASE EMBL [online] 1 March 2001 (2001-03-01), WIEMANN ET AL: "Towards a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs", XP002219790, retrieved from EMBL Database accession no. Q9H015
DATABASE EMBL [online] 1 December 2001 (2001-12-01), TASHIRO ET AL: "NEDO human cDNA sequencing project", XP002219791, retrieved from EMBL Database accession no. Q96LR9
DATABASE EMBL [online] 7 April 1999 (1999-04-07), MUZNY ET AL: "Direct Submission", XP002219792, retrieved from EMBL Database accession no. AC007215
FROSSARD P M ET AL: "ASSOCIATION BETWEEN A DIMORPHIC SITE ON CHROMOSOME 12 AND CLINICAL DIAGNOSIS OF HYPERTENSION IN THREE INDEPENDENT POPULATIONS", CLINICAL GENETICS, COPENHAGEN, DK, vol. 48, no. 6, 1 December 1995 (1995-12-01), pages 284 - 287, XP002043529
HORREVOETS A J G ET AL: "VASCULAR ENDOTHELIAL GENES THAT ARE RESPONSIVE TO TUMOR NECROSIS FACTOR-ALPHA IN VITRO ARE EXPRESSED IN ATHEROSCLEROTIC LESIONS, INCLUDING INHIBITOR OF APOPTOSIS PROTEIN-1, STANNIN, AND TWO NOVEL GENES", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 93, no. 10, 15 May 1999 (1999-05-15), pages 3418 - 3431, XP002936412, ISSN: 0006-4971
DATABASE EMBL [online] 1 December 2001 (2001-12-01), TASHIRO ET AL: "NEDO human cDNA sequencing project", XP002219791, retrieved from EMBL Database accession no. Q96LR9
DATABASE EMBL [online] 7 April 1999 (1999-04-07), MUZNY ET AL: "Direct Submission", XP002219792, retrieved from EMBL Database accession no. AC007215
FROSSARD P M ET AL: "ASSOCIATION BETWEEN A DIMORPHIC SITE ON CHROMOSOME 12 AND CLINICAL DIAGNOSIS OF HYPERTENSION IN THREE INDEPENDENT POPULATIONS", CLINICAL GENETICS, COPENHAGEN, DK, vol. 48, no. 6, 1 December 1995 (1995-12-01), pages 284 - 287, XP002043529
HORREVOETS A J G ET AL: "VASCULAR ENDOTHELIAL GENES THAT ARE RESPONSIVE TO TUMOR NECROSIS FACTOR-ALPHA IN VITRO ARE EXPRESSED IN ATHEROSCLEROTIC LESIONS, INCLUDING INHIBITOR OF APOPTOSIS PROTEIN-1, STANNIN, AND TWO NOVEL GENES", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 93, no. 10, 15 May 1999 (1999-05-15), pages 3418 - 3431, XP002936412, ISSN: 0006-4971
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