Title:
NOVEL EXOSOME-BASED ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2018/124835
Kind Code:
A1
Abstract:
The present invention provides a recombinant exosome having phagocytosis-promoting protein presented on the surface thereof and the use thereof.
Inventors:
KOH EUN-EE (KR)
LEE EUN JUNG (KR)
YANG YOO SOO (KR)
KIM IN-SAN (KR)
LEE EUN JUNG (KR)
YANG YOO SOO (KR)
KIM IN-SAN (KR)
Application Number:
PCT/KR2017/015784
Publication Date:
July 05, 2018
Filing Date:
December 29, 2017
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
A61K9/127; A61K31/505; A61K31/519; A61K31/69; A61K31/704; A61K45/06; A61K47/68; A61K47/69; C07K14/47
Domestic Patent References:
| WO2016201323A1 | 2016-12-15 |
Foreign References:
| US20150329616A1 | 2015-11-19 | |||
| US20150376288A1 | 2015-12-31 |
Other References:
WEISKOPF, K. ET AL.: "Engineered SIRPa Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies", SCIENCE, vol. 341, no. 6141, 5 July 2013 (2013-07-05), pages 88 - 91, XP055488633
TIAN, Y . ET AL.: "A Doxorubicin Delivery Platform Using Engineered Natural Membrane Vesicle Exosomes for Targeted Tumor Therapy", BIOMATERIALS, vol. 35, no. 7, February 2014 (2014-02-01), pages 2383 - 2390, XP028807713
KOH, E. ET AL.: "Exosome-SIRPalpha, a CD 47 Blockade Increases Cancer Cell Phagocytosis", BIOMATERIALS, vol. 121, 3 January 2017 (2017-01-03), pages 121 - 129, XP029890674
PARDOLL, D.M., NAT. REV. CANCER, vol. 12, 2012, pages 252 - 264
TSENG, D. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 110, 2013, pages 11103 - 11108
SOCKOLOSKY, J.T. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 113, 2016, pages E2646 - E2654
WEISKOPF ET AL., SCIENCE, vol. 341, no. 6141, 2013, pages 88 - 91
See also references of EP 3563835A4
TIAN, Y . ET AL.: "A Doxorubicin Delivery Platform Using Engineered Natural Membrane Vesicle Exosomes for Targeted Tumor Therapy", BIOMATERIALS, vol. 35, no. 7, February 2014 (2014-02-01), pages 2383 - 2390, XP028807713
KOH, E. ET AL.: "Exosome-SIRPalpha, a CD 47 Blockade Increases Cancer Cell Phagocytosis", BIOMATERIALS, vol. 121, 3 January 2017 (2017-01-03), pages 121 - 129, XP029890674
PARDOLL, D.M., NAT. REV. CANCER, vol. 12, 2012, pages 252 - 264
TSENG, D. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 110, 2013, pages 11103 - 11108
SOCKOLOSKY, J.T. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 113, 2016, pages E2646 - E2654
WEISKOPF ET AL., SCIENCE, vol. 341, no. 6141, 2013, pages 88 - 91
See also references of EP 3563835A4
Attorney, Agent or Firm:
HAN, Yun Ho (KR)
Download PDF: