NOVEL INSULIN/IGF/RELAXIN FAMILY POLYPEPTIDES AND DNAS THEREOF

WIPO Patent Application WO/2001/081562

A1

(1) A polypeptide having an amino acid sequence being identical or substantially identical with the amino acid sequence represented by SEQ ID NO:7 (strand A); (2) a polypeptide having an amino acid sequence being identical or substantially identical with the amino acid sequence represented by SEQ ID NO:8 (strand B); (3) a polypeptide wherein the strand A and B are bonded to each other via a disulfide bond (double-stranded) or its salt; (4) DNAs encoding the same, etc. These polypeptides and DNAs encoding the same are usable in, for example, diagnosing, treating and preventing diseases (diabetics, etc.) caused by metabolic errors of energy sources such as carbohydrates (for example, sugar metabolism, lipid metabolism).

ITOH YASUAKI (JP)
SUZUKI NOBUHIRO (JP)
NISHI KAZUNORI (JP)
KIZAWA HIDEKI (JP)
HARADA MASATAKA (JP)
OGI KAZUHIRO (JP)

PCT/JP2001/003399

November 01, 2001

April 20, 2001

Click for automatic bibliography generation  

TAKEDA CHEMICAL INDUSTRIES LTD (JP)
ITOH YASUAKI (JP)
SUZUKI NOBUHIRO (JP)
NISHI KAZUNORI (JP)
KIZAWA HIDEKI (JP)
HARADA MASATAKA (JP)
OGI KAZUHIRO (JP)

G01N33/50; A61K31/7088; A61K38/00; A61K38/22; A61K38/27; A61K38/28; A61K39/395; A61K45/00; A61K48/00; A61P1/16; A61P3/00; A61P5/00; A61P9/00; A61P11/00; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P25/00; A61P37/00; A61P43/00; C07H21/04; C07K14/47; C07K14/575; C07K14/62; C07K14/64; C07K14/65; C07K16/26; C12N1/15; C12N1/19; C12N1/21; C12N5/06; C12N5/10; C12N15/09; C12P21/02; C12P21/08; G01N33/15; G01N33/53; G01N33/566; G01N33/74; A61K39/00; (IPC1-7): C12N15/09; C07K14/65; C07K16/26; C12N1/15; C12N1/19; C12N1/21; C12N5/00; C12Q1/68; C12P21/02; C12P21/08; A61K38/17; A61K38/28; A61K38/30; A61K39/395; A61K45/00; A61P43/00; A61P3/00; A61P19/00; A61P9/00; A61P5/00; A61P25/00; A61P37/00; A61P1/16; A61P11/00; A61P17/00; G01N33/50; G01N33/15

WO2000021996A2	2000-04-20
WO2000047776A2	2000-08-17
WO2000032221A2	2000-06-08
WO1999015664A1	1999-04-01

ERIKA E. BULLESBACH ET AL.: "Isolation, purification and the sequence of relaxin from spiny dogfish (squalus acanthias)", EUR J. BIOCHEM., vol. 161, 1986, pages 335 - 341, XP002943482
L.K. GOWAN ET AL.: "On the primary and tertiary structure of relaxin from the sand tiger shark (odontaspis taurus)", FEBS LETT., vol. 129, no. 1, 1981, pages 80 - 82, XP002943483
JOHN HALEY ET AL.: "Porcine relaxin gene structure and expression", J. BIOL. CHEM., vol. 262, no. 26, 1987, pages 11940 - 11946, XP002943484
ROBERT JAMES, HUGH NIALL: "Primary structure of porcine relaxin: homology with insulin and related growth factors", NATURE, vol. 267, no. 9, 1977, pages 544 - 546, XP002943485
S. BERGER ET AL.: "Statistical approach for evolutionary relationship of alpha - conotoxins and members of insulin-superfamily", HORM. METAB. RES., vol. 28, 1996, pages 535 - 540, XP002943486
See also references of EP 1283260A4

Takahashi, Shuichi (Ltd. 17-85, Jusohonmachi 2-chome Yodogawa-ku Osaka-shi Osaka, JP)

View/Download PDF      PDF Help

Previous Patent: 26335, A NOVEL HUMAN SERINE/THREONINE DEHYDRATASE AND USES THEREOF

Next Patent: Method for producing DNA encoding polypeptides that are composed of several sections, and for produc...