NOVEL FAST-DISSOLVING GRANULE FORMULATION HAVING IMPROVED SOLUBILITY

Title:

NOVEL FAST-DISSOLVING GRANULE FORMULATION HAVING IMPROVED SOLUBILITY

Document Type and Number:

WIPO Patent Application WO/2014/106962

Kind Code:

A1

Abstract:

The present invention relates to a fast-dissolving granule formulation which is dissolved quickly in the mouth. The present invention provides a fast-dissolving granule formulation which quickly dissolves within 20 seconds in the mouth when administered orally, and which causes no feelings of irritation resulting from foreign matter or residue. The granule formulation of the present invention is obtained by assembling a fast-dissolving carrier and an active ingredient, wherein the fast-dissolving carrier satisfies the conditions of having an instantaneous solubility of 30mg/ml or more, solubility of 50mg/ml or more within five minutes, and the instantaneous solubility is 90% or less than the maximum solubility. The granule formulation may achieve effects of the present invention regardless of the type of the active ingredient and therefore can be applied to various active ingredients. Further, since the present invention provides a relatively simple preparation process, a high efficiency process can be constructed at a low cost.

Inventors:

LEE JONG HOON (KR)
SHIM SANG BO (KR)
KIM SANG WOOK (KR)
YI HONG GI (KR)

Application Number:

PCT/KR2013/000107

Publication Date:

July 10, 2014

Filing Date:

January 07, 2013

Export Citation:

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Assignee:

SAM A PHARM CO LTD (KR)

International Classes:

A61K9/16; A61K9/14; A61K47/30; A61K47/36

Foreign References:

KR100554924B1	2006-03-03
KR20010014099A	2001-02-26
KR20080112320A	2008-12-24
KR100367483B1	2003-03-26
KR20050044512A	2005-05-12
US20110027377A1	2011-02-03
US20110117193A1	2011-05-19
KR20070062978A	2007-06-18
KR20090086469A	2009-08-12
US5169643A	1992-12-08
US5532209A	1996-07-02

Other References: