Title:
NOVEL FERMENTATION PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2005/092916
Kind Code:
A1
Abstract:
As the results of studies for searching for a substance capable of selectively inducing cell death into a tumor cell with the use of cells having an oncogene transferred thereinto, it is found out that novel peptide-type fermentation products obtained from a ray fungus belonging to the genus Streptomyces have a potent and selective cytotoxic activity on cells having an oncogene transferred thereinto. Namely, it is intended to provide peptide-type fermentation products having a potent and selective cytotoxic activity which comprise a linear moiety having a large number of thioamide bonds and a cyclic moiety consisting of five amino acid residues and pharmaceutically acceptable salts thereof.
Inventors:
NAGAI KOJI (JP)
TAKEDA YASUYO (JP)
HAYAKAWA YOICHI (JP)
TAKEDA YASUYO (JP)
HAYAKAWA YOICHI (JP)
Application Number:
PCT/JP2005/005353
Publication Date:
October 06, 2005
Filing Date:
March 24, 2005
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
NAGAI KOJI (JP)
TAKEDA YASUYO (JP)
HAYAKAWA YOICHI (JP)
NAGAI KOJI (JP)
TAKEDA YASUYO (JP)
HAYAKAWA YOICHI (JP)
International Classes:
A61K35/74; A61K38/00; A61K38/05; A61P35/00; C07K7/54; C12N1/20; C12P17/14; C12P21/02; C12P21/04; C12R1/465; (IPC1-7): C07K7/54; A61K35/74; A61K38/00; A61P35/00; C12N1/20; C12P21/04
Foreign References:
| JPH06316595A | 1994-11-15 |
Other References:
VANDRE DD. ET AL: "Antitumor proteins of Streptomyces macromomyceticus: purification and characterization of auromomycin A, and macromomycin D.", BIOCHEMISTRY., vol. 21, no. 14, 1982, pages 3343 - 3352, XP002989875
Attorney, Agent or Firm:
Morita, Hiroshi c/o Astellas Pharma Inc. Intellectual Property (3-11 Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)
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