NOVEL FLUORESCENT AMINO ACID DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

Title:

NOVEL FLUORESCENT AMINO ACID DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/2008/004529

Kind Code:

A1

Abstract:

A novel fluorescent amino acid derivative that can be synthesized through a simple process and that can be excited by visible rays, especially those of blue laser light region, exhibiting high photostability; and a process for producing the same. There is provided a fluorescent amino acid derivative comprised of an acridone derivative substituted with an amino acid wherein an electrophilic substituent is contained between the amino acid and the acridone derivative. There is provided a process comprising, in place of the conventional procedure of forming a fluorophore through subjecting aminophenylalanine as a starting material to coupling reaction and intramolecular cyclization reaction, subjecting a fluorescent acridone derivative as a starting material substance to site-specific electrophilic substitution reaction to thereby generate a reactive point and coupling the acridone derivative with the reactive point with an amino acid derivative.

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Inventors:

TAKI MASUMI (JP)
SISIDO MASAHIKO (JP)

Application Number:

PCT/JP2007/063261

Publication Date:

January 10, 2008

Filing Date:

July 03, 2007

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Assignee:

UNIV OKAYAMA NAT UNIV CORP (JP)
TAKI MASUMI (JP)
SISIDO MASAHIKO (JP)

International Classes:

C09K11/06; C07D219/06

Foreign References:

JPH0543574A	1993-02-23
JP2005287327A	2005-10-20
JP2005500406A	2005-01-06
JP2005534738A	2005-11-17

Other References:

SZYMANSKA A. ET AL.: "Synthesis of N-[(tert-butoxy)carbonyl)-3-(9,10-dihydro-9-oxoacridin-2-yl)-L-alanine, a new fluorescent amino acid derivative", HELVETICA CHIMICA ACTA, vol. 86, no. 10, 2003, pages 3326 - 3331, XP003020551

Attorney, Agent or Firm:

SHOJI, Takashi et al. (2-10 Iwamotocho 3-chome Chiyoda-k, Tokyo 32, JP)

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