Title:
NOVEL FLUORESCENT COMPOUND HAVING LARGE STOKES SHIFT
Document Type and Number:
WIPO Patent Application WO/2021/254321
Kind Code:
A1
Abstract:
The invention relates to the field of fluorescent dye, specifically, a novel fluorescent compound having large Stokes shift. Said fluorescent compound can be used for nucleic acid and polypeptide modifications, and the Stokes shift can be up to approximately 190nm, that is, having a large wavelength difference between maximum emission wavelength and maximum excitation wavelength. Thereby, the problems of self-quenching and measurement error caused by crosstalk and backscattering during measurement are solved.
Inventors:
CHEN JINSEN (CN)
ZHANG YOUFU (CN)
LI HONG (CN)
WANG JIANPENG (CN)
ZHANG YOUFU (CN)
LI HONG (CN)
WANG JIANPENG (CN)
Application Number:
PCT/CN2021/100087
Publication Date:
December 23, 2021
Filing Date:
June 15, 2021
Export Citation:
Assignee:
NANJING GENSCRIPT BIOTECH CO LTD (CN)
International Classes:
C09B23/00; C07D405/02; C09K11/06; C12Q1/68
Domestic Patent References:
| WO2001094473A1 | 2001-12-13 |
Foreign References:
| CN102942566A | 2013-02-27 |
Other References:
DAI YANPENG; ZHENG YU; XUE TIANZI; HE FANGRU; JI HEFANG; QI ZHENGJIAN: "A novel fluorescent probe for rapidly detection cysteine in cystinuria urine, living cancer/normal cells and BALB/c nude mice", SPECTROCHIMICA ACTA PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, ELSEVIER, AMSTERDAM, NL, vol. 225, 27 August 2019 (2019-08-27), AMSTERDAM, NL, XP085961493, ISSN: 1386-1425, DOI: 10.1016/j.saa.2019.117490
IKEDA SHUJI, YANAGISAWA HIROYUKI, NAKAMURA AKIKO, WANG DAN OHTAN, YUKI MIZUE, OKAMOTO AKIMITSU: "Hybridization-sensitive fluorescence control in the near-infrared wavelength range", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 9, 1 January 2011 (2011-01-01), pages 4199 - 4204, XP055822137, ISSN: 1477-0520, DOI: 10.1039/c1ob05252g
ZHANG SHUWEI; WU DONGDONG; WU JUANJUAN; XIA QIANWEN; JIA XIAODONG; SONG XIAOLI; ZENG LINTAO; YUAN YU: "A water-soluble near-infrared fluorescent probe for sensitive and selective detection of cysteine", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 204, 19 June 2019 (2019-06-19), NL , pages 747 - 752, XP085747178, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2019.06.074
IKEDA SHUJI, YANAGISAWA HIROYUKI, NAKAMURA AKIKO, WANG DAN OHTAN, YUKI MIZUE, OKAMOTO AKIMITSU: "Hybridization-sensitive fluorescence control in the near-infrared wavelength range", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 9, 1 January 2011 (2011-01-01), pages 4199 - 4204, XP055822137, ISSN: 1477-0520, DOI: 10.1039/c1ob05252g
ZHANG SHUWEI; WU DONGDONG; WU JUANJUAN; XIA QIANWEN; JIA XIAODONG; SONG XIAOLI; ZENG LINTAO; YUAN YU: "A water-soluble near-infrared fluorescent probe for sensitive and selective detection of cysteine", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 204, 19 June 2019 (2019-06-19), NL , pages 747 - 752, XP085747178, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2019.06.074
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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