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Title:
NOVEL FLUORESCENTLY LABELED SPHINGOMYELIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/148125
Kind Code:
A1
Abstract:
A compound represented by formula (1) (wherein A represents a residue of a water-soluble fluorescence-emitting compound; B and E represent linkers which are the same as or different from each other; R1 to R4 independently represent a hydrogen atom or an alkyl group which may be substituted; X represents 3 to 50; m and n independently represent 10 to 30; and the group represented by formula (2) represents a single bond or a double bond) is novel fluorescently labeled sphingomyelin that exhibits the same behavior as that of native sphingomyelin. The use of the fluorescently labeled sphingomyelin makes it possible to provide: a lipid raft visualizing agent, a diagnosis marker for a lipid raft-related disease, a reagent for detecting or quantifying a lipid raft, and a method for visualizing a lipid raft.

Inventors:
MURATA MICHIO (JP)
MATSUMORI NOBUAKI (JP)
KINOSHITA MASANAO (JP)
KUSUMI AKIHIRO (JP)
SUZUKI KENICHI (JP)
Application Number:
PCT/JP2016/058079
Publication Date:
September 22, 2016
Filing Date:
March 15, 2016
Export Citation:
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Assignee:
UNIV OSAKA (JP)
UNIV KYOTO (JP)
International Classes:
C09B69/10; C08G65/333; C08G65/335; C09B11/28; G01N33/58; G01N33/92
Domestic Patent References:
WO2007102396A12007-09-13
Foreign References:
JP2003344419A2003-12-03
US20050026235A12005-02-03
US20120028290A12012-02-02
Other References:
ISHITSUKA, REIKO ET AL.: "Imaging Lipid Rafts", J. BIOCHEM., vol. 137, 2005, pages 249 - 254, XP055311887
MUKHERJEE, SOUMI ET AL.: "Organization and dynamics of N-(7-nitrobenz-2-oxa-1,3-diazol-4- yl)-labeled lipids: a fluorescence approach", CHEMISTRY AND PHYSICS OF LIPIDS, vol. 127, 2004, pages 91 - 101, XP055311889
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
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