Title:
NOVEL FORM OF ISOQUINOLINESULFONAMIDE
Document Type and Number:
WIPO Patent Application WO/2020/129876
Kind Code:
A1
Abstract:
The purpose of the present invention is to acquire a stable crystal of a salt of N-[(R)-1-\{(S)-2-hydroxy-2-phenylpropylamino\}propan-2-yl]isoquinoline-6-sulfonamide, the crystal, as a material for medicines, having desirable properties. The salt is N-[(R)-1-\{(S)-2-hydroxy-2-phenylpropylamino\}propan-2-yl]isoquinoline-6-sulfonamide dihydrochloride anhydrate.
Inventors:
HIDAKA HIROYOSHI (JP)
SUMI KENGO (JP)
IZUHARA TAKASHI (JP)
SUMI KENGO (JP)
IZUHARA TAKASHI (JP)
Application Number:
PCT/JP2019/049099
Publication Date:
June 25, 2020
Filing Date:
December 16, 2019
Export Citation:
Assignee:
D WESTERN THERAPEUTICS INST INC (JP)
International Classes:
C07D217/02; A61K31/472; A61P9/12; A61P27/06
Domestic Patent References:
| WO2012086727A1 | 2012-06-28 | |||
| WO2012086727A1 | 2012-06-28 | |||
| WO2006057397A1 | 2006-06-01 | |||
| WO2009004792A1 | 2009-01-08 |
Foreign References:
| JP2899953B2 | 1999-06-02 | |||
| JP5819705B2 | 2015-11-24 |
Other References:
NORIYUKI TAKATA: "Soyaku Dankai ni Okeru Gen'yaku Form Screening to Sentaku - API form screening and selection in drug discovery stage", PHARM STAGE, TECHNICAL INFORMATION INSTITUTE, JP, vol. 6, no. 10, 1 January 2007 (2007-01-01), JP, pages 20 - 25, XP008145548, ISSN: 1346-3918
C G WERMUTH : "The practice of medical chemistry ", 1 January 1999, TEKUNOMIKKU, JP, ISBN: 978-4-924746-80-0, article BRADLEY D ANDSERSON , KARL P FLORA , pages: 347 - 365, XP009508529
HIRAYAMA NORIAKI: "Handbook of organic compounds crystallization - principles and know-how", 2008, JP, ISBN: 978-4-621-07991-1, article HIRAYAMA, NORIAKI: "Passage, Chapter 3 & 4; Organic compound crystal preparation handbook - principle and knowhow", pages: 37 - 84, XP009519818
OGATA, AKIRA: "Passage; How to Conduct Chemical Experiments", HOW TO CONDUCT CHEMICAL EXPERIMENTS, 1963, pages 372,390 - 391, XP009528362
See also references of EP 3901141A4
C G WERMUTH : "The practice of medical chemistry ", 1 January 1999, TEKUNOMIKKU, JP, ISBN: 978-4-924746-80-0, article BRADLEY D ANDSERSON , KARL P FLORA , pages: 347 - 365, XP009508529
HIRAYAMA NORIAKI: "Handbook of organic compounds crystallization - principles and know-how", 2008, JP, ISBN: 978-4-621-07991-1, article HIRAYAMA, NORIAKI: "Passage, Chapter 3 & 4; Organic compound crystal preparation handbook - principle and knowhow", pages: 37 - 84, XP009519818
OGATA, AKIRA: "Passage; How to Conduct Chemical Experiments", HOW TO CONDUCT CHEMICAL EXPERIMENTS, 1963, pages 372,390 - 391, XP009528362
See also references of EP 3901141A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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