Title:
NOVEL FUSANT AND METHOD FOR DETECTING SAME
Document Type and Number:
WIPO Patent Application WO/2015/111716
Kind Code:
A1
Abstract:
Provided are a method for elucidating a polynucleotide which is a novel gene responsible for cancer, and detecting the polynucleotide or the polypeptide coded thereby on the basis of this finding; a kit and primer set for this detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for cancer treatment containing the inhibitor. In this detection method, a FGFR3 fusion protein or a fusion gene for encoding said fusion protein, or a TACC3 fusion protein or a fusion gene for encoding said fusion protein, is detected in a sample derived from female genitalia obtained from a subject.
Inventors:
TAKEUCHI KENGO (JP)
Application Number:
PCT/JP2015/051892
Publication Date:
July 30, 2015
Filing Date:
January 23, 2015
Export Citation:
Assignee:
JAPAN FOUND CANCER (JP)
International Classes:
C12N15/09; A61K38/55; A61K45/00; A61P15/00; A61P15/02; A61P35/00; C12Q1/68; G01N33/15; G01N33/50; G01N33/68
Domestic Patent References:
| WO2013165008A1 | 2013-11-07 | |||
| WO2011162295A1 | 2011-12-29 | |||
| WO2013133351A1 | 2013-09-12 |
Foreign References:
| JP2012005479A | 2012-01-12 | |||
| JP4303303B2 | 2009-07-29 | |||
| JP2012100628A | 2012-05-31 |
Other References:
RONG WU: "Somatic mutations ot fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix", ONCOGENE, vol. 19, 2000, pages 5543 - 5546, XP055214895
DAVID CAPPELLEN: "Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas", NATURE GENETICS, vol. 23, 1999, pages 18 - 20, XP002181676
REBECCA K. TYLER: "VX-680 Inhibits Aurora A and Aurora B Kinase Activity in Human Cells", CELL CYCLE, vol. 6, no. ISSUE, 2007, pages 2846 - 2854, XP055214899
IVAN BABIC: "Multiple functions of a glioblastoma fusion oncogene", JOURNAL OF CLINICAL INVESTIGATION, vol. 123, no. 2, 2013, pages 548 - 551, XP055214901
LUGO TG; PENDERGAST AM; MULLER AJ; WITTE ON: "Tyrosine kinase activity and transformation potency of bcr-abl oncogene products", SCIENCE, vol. 247, no. 4946, 2 March 1990 (1990-03-02), pages 1079 - 1082
SINGH D ET AL.: "Transforming fusions of FGFR and TACC genes in human glioblastoma", SCIENCE, vol. 337, no. 6099, 7 September 2012 (2012-09-07), pages 1231 - 1235, XP055237736, DOI: doi:10.1126/science.1220834
WILLIAMS SV ET AL.: "Oncogenic FGFR3 gene fusions in bladder cancer", HUM MOL GENET., vol. 22, no. 4, 15 February 2013 (2013-02-15), pages 795 - 803, XP055128302, DOI: doi:10.1093/hmg/dds486
MAJEWSKI IJ: "Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing", J PATHOL, vol. 230, no. 3, July 2013 (2013-07-01), pages 270 - 276, XP055077319, DOI: doi:10.1002/path.4209
J MOL BIOL, vol. 48, 1970, pages 443 - 453
METZKER ML, NAT REV GENET., vol. 11, no. 1, January 2010 (2010-01-01), pages 31 - 46
GENOME RES., vol. 6, no. 10, 1996, pages 986
TAKEUCHI ET AL., CLIN CANCER RES, vol. 15, no. 9, 1 May 2009 (2009-05-01), pages 3143 - 3149
"Molecular Cloning: A Laboratory Manual 4th Edition", 2012, COLD SPRING HARBOR LABORATORY PRESS
ZHAO G ET AL., MOL CANCER THER., vol. 10, no. 11, November 2011 (2011-11-01), pages 2200 - 2010
MIYAKE M ET AL., J PHARMACOL EXP THER., vol. 332, no. 3, March 2010 (2010-03-01), pages 795 - 802
GRAND EK ET AL., LEUKEMIA, vol. 18, no. 5, May 2004 (2004-05-01), pages 962 - 966
TRUDEL S ET AL., BLOOD, vol. 105, no. 7, 1 April 2005 (2005-04-01), pages 2941 - 2948
DUBREUIL P ET AL., PLOS ONE, vol. 4, no. 9, 30 September 2009 (2009-09-30), pages E7258
KATOH, M.; NAKAGAMA, H., MED. RES. REV., May 2013 (2013-05-01)
CHENG T ET AL., PLOS ONE, vol. 8, no. 2, 2013, pages E57284
GAVINE PR ET AL., CANCER RES., vol. 72, no. 8, 15 April 2012 (2012-04-15), pages 2045 - 2056
WURDAK H. ET AL., PROC NATL ACAD SCI USA., vol. 107, no. 38, 21 September 2010 (2010-09-21), pages 16542 - 7
GENES DEV, vol. 15, 2001, pages 485 - 490
J. AM. CHEM. SOC., vol. 120, 1998, pages 11820 - 11821
METHODS, vol. 23, 2001, pages 206 - 217
J. SAMBROOK, E. F. FRITSCH & T. MANIATIS: "Molecular cloning, a laboratory manual (3rd edition)", 2001, COLD SPRING HARBOR PRESS
F. M. AUSUBEL, R. BRENT, R. E. KINGSTON, D. D. MOORE, J.G. SEIDMAN, J. A. SMITH, K. STRUHL: "Current Protocols in Molecular Biology", JOHN WILEY & SONS LTD.
TAKEUCHI K; CHOI YL; SODA M; INAMURA K; TOGASHI Y; HATANO S; ENOMOTO M; TAKADA S; YAMASHITA Y; SATOH Y: "Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts", CLIN CANCER RES., vol. 14, 2008, pages 6618 - 6624, XP055052558, DOI: doi:10.1158/1078-0432.CCR-08-1018
See also references of EP 3098312A4
DAVID CAPPELLEN: "Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas", NATURE GENETICS, vol. 23, 1999, pages 18 - 20, XP002181676
REBECCA K. TYLER: "VX-680 Inhibits Aurora A and Aurora B Kinase Activity in Human Cells", CELL CYCLE, vol. 6, no. ISSUE, 2007, pages 2846 - 2854, XP055214899
IVAN BABIC: "Multiple functions of a glioblastoma fusion oncogene", JOURNAL OF CLINICAL INVESTIGATION, vol. 123, no. 2, 2013, pages 548 - 551, XP055214901
LUGO TG; PENDERGAST AM; MULLER AJ; WITTE ON: "Tyrosine kinase activity and transformation potency of bcr-abl oncogene products", SCIENCE, vol. 247, no. 4946, 2 March 1990 (1990-03-02), pages 1079 - 1082
SINGH D ET AL.: "Transforming fusions of FGFR and TACC genes in human glioblastoma", SCIENCE, vol. 337, no. 6099, 7 September 2012 (2012-09-07), pages 1231 - 1235, XP055237736, DOI: doi:10.1126/science.1220834
WILLIAMS SV ET AL.: "Oncogenic FGFR3 gene fusions in bladder cancer", HUM MOL GENET., vol. 22, no. 4, 15 February 2013 (2013-02-15), pages 795 - 803, XP055128302, DOI: doi:10.1093/hmg/dds486
MAJEWSKI IJ: "Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing", J PATHOL, vol. 230, no. 3, July 2013 (2013-07-01), pages 270 - 276, XP055077319, DOI: doi:10.1002/path.4209
J MOL BIOL, vol. 48, 1970, pages 443 - 453
METZKER ML, NAT REV GENET., vol. 11, no. 1, January 2010 (2010-01-01), pages 31 - 46
GENOME RES., vol. 6, no. 10, 1996, pages 986
TAKEUCHI ET AL., CLIN CANCER RES, vol. 15, no. 9, 1 May 2009 (2009-05-01), pages 3143 - 3149
"Molecular Cloning: A Laboratory Manual 4th Edition", 2012, COLD SPRING HARBOR LABORATORY PRESS
ZHAO G ET AL., MOL CANCER THER., vol. 10, no. 11, November 2011 (2011-11-01), pages 2200 - 2010
MIYAKE M ET AL., J PHARMACOL EXP THER., vol. 332, no. 3, March 2010 (2010-03-01), pages 795 - 802
GRAND EK ET AL., LEUKEMIA, vol. 18, no. 5, May 2004 (2004-05-01), pages 962 - 966
TRUDEL S ET AL., BLOOD, vol. 105, no. 7, 1 April 2005 (2005-04-01), pages 2941 - 2948
DUBREUIL P ET AL., PLOS ONE, vol. 4, no. 9, 30 September 2009 (2009-09-30), pages E7258
KATOH, M.; NAKAGAMA, H., MED. RES. REV., May 2013 (2013-05-01)
CHENG T ET AL., PLOS ONE, vol. 8, no. 2, 2013, pages E57284
GAVINE PR ET AL., CANCER RES., vol. 72, no. 8, 15 April 2012 (2012-04-15), pages 2045 - 2056
WURDAK H. ET AL., PROC NATL ACAD SCI USA., vol. 107, no. 38, 21 September 2010 (2010-09-21), pages 16542 - 7
GENES DEV, vol. 15, 2001, pages 485 - 490
J. AM. CHEM. SOC., vol. 120, 1998, pages 11820 - 11821
METHODS, vol. 23, 2001, pages 206 - 217
J. SAMBROOK, E. F. FRITSCH & T. MANIATIS: "Molecular cloning, a laboratory manual (3rd edition)", 2001, COLD SPRING HARBOR PRESS
F. M. AUSUBEL, R. BRENT, R. E. KINGSTON, D. D. MOORE, J.G. SEIDMAN, J. A. SMITH, K. STRUHL: "Current Protocols in Molecular Biology", JOHN WILEY & SONS LTD.
TAKEUCHI K; CHOI YL; SODA M; INAMURA K; TOGASHI Y; HATANO S; ENOMOTO M; TAKADA S; YAMASHITA Y; SATOH Y: "Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts", CLIN CANCER RES., vol. 14, 2008, pages 6618 - 6624, XP055052558, DOI: doi:10.1158/1078-0432.CCR-08-1018
See also references of EP 3098312A4
Attorney, Agent or Firm:
MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)
Ken-ichi Morita (JP)
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