Title:
NOVEL FUSED HETEROCYCLIC COMPOUND AND ANTIASTHMATIC AGENT PREPARED THEREFROM
Document Type and Number:
WIPO Patent Application WO/1991/012251
Kind Code:
A1
Abstract:
A compound of general formula (I) and a pharmaceutically acceptable acid addition salt thereof, which have both bronchodilating and thromboxane A�2? synthetase inhibiting actions, and are useful as antiasthmatic agent and bronchodilator, wherein (a) represents an unsaturated five- or six-membered ring with 0 or 1 nitrogen atom and 0 or 1 sulfur atom; R�1? represents hydrogen, halogen, carboxyl, lower alkoxycarbonyl, nitro or lower alkoxy; R�2? represents lower alkyl, cyclohexyl, (un)substituted benzyl, thienylmethyl, (un)substituted unsaturated five- or six-membered ring with 1 to 3 nitrogen atoms and 0 to 1 sulfur atom, or (un)substituted phenyl; and R�3? represents lower alkyl, lower alkenyl, lower alkynyl, aralkyl, cycloalkyl, cycloalkylmethyl, acyl, acylmethyl, benzenesulfonyl, (un)substituted lower alkyl, or (b) (wherein B represents an open-chain hydrocarbon group).
Inventors:
OHI NOBUHIRO (JP)
KUROKI TOSHIO (JP)
YAMAGUCHI MASAHISA (JP)
AKIMA MICHITAKA (JP)
KOGA TAKAKI (JP)
KAMEI KENSHI (JP)
KUROKI TOSHIO (JP)
YAMAGUCHI MASAHISA (JP)
AKIMA MICHITAKA (JP)
KOGA TAKAKI (JP)
KAMEI KENSHI (JP)
Application Number:
PCT/JP1991/000210
Publication Date:
August 22, 1991
Filing Date:
February 19, 1991
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D401/04; C07D409/04; C07D471/04; C07D495/04; (IPC1-7): A61K31/50; C07D401/04; C07D401/14; C07D403/04; C07D403/06; C07D403/14; C07D405/04; C07D405/14; C07D409/04; C07D409/14; C07D417/04; C07D417/14; C07D471/04; C07D495/04; C12N9/99
Foreign References:
| JPS6419077A | 1989-01-23 | |||
| JPS63150278A | 1988-06-22 | |||
| JPS63280078A | 1988-11-17 | |||
| JPS62298573A | 1987-12-25 | |||
| JPS6051173A | 1985-03-22 | |||
| FR2478640A1 | 1981-09-25 | |||
| FR1453897A | 1966-07-22 |
Attorney, Agent or Firm:
Yuasa, Kyozo (Section 206 Shin Ohtemachi Bldg., 2-1,
Ohtemachi 2-chom, Chiyoda-ku Tokyo 100, JP)
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