Title:
NOVEL FUSION GENE AS FACTOR RESPONSIBLE FOR STOMACH CANCER
Document Type and Number:
WIPO Patent Application WO/2015/093557
Kind Code:
A1
Abstract:
The purpose of the present invention is to: identify a mutation that can serve as an indicator for predicting the efficacy of treatment of stomach cancer or another such cancer by a drug; provide a means for detecting the mutation; and provide means for identifying, on the basis of on this mutation, a cancer patient or subject at risk for cancer in whom a drug that targets a gene having this mutation or a protein encoded thereby will have a therapeutic effect. A method for detecting a gene fusion which is a mutation (driver mutation) responsible for cancer, said method including a step for detecting, in a sample isolated from a subject, any fusion polynucleotide among ATG3-EPHB1 fusion polynucleotide, TNIK-RNF123 fusion polynucleotide, or SLC12A2-NRG2 fusion polynucleotide, or a polypeptide encoded by this fusion polynucleotide.
Inventors:
SHIBATA TATSUHIRO (JP)
HOSODA FUMIE (JP)
HOSODA FUMIE (JP)
Application Number:
PCT/JP2014/083526
Publication Date:
June 25, 2015
Filing Date:
December 18, 2014
Export Citation:
Assignee:
NAT CANCER CT (JP)
LSIP LLC (JP)
LSIP LLC (JP)
International Classes:
C12N15/09; A61K45/00; A61P35/00; C07K19/00; C12N9/12; C12Q1/68; G01N33/574; C07K16/40
Domestic Patent References:
| WO2013133351A1 | 2013-09-12 | |||
| WO2010064111A1 | 2010-06-10 |
Other References:
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CHO GEUN-A ET AL.: "Abstract 5078: Identification of novel gene fusions by RNA-seq in gastric cancer", CANCER RESEARCH, vol. 72, no. SUPPL., 2012, pages 5078
YUN SUN MI: "Abstract 4304: PPP1R1B-STARD3 fusion gene promotes gastric tumorigenesis through activation of PI3K/Akt signaling.", CANCER RESEARCH, vol. 73, no. SUPPL., April 2013 (2013-04-01), pages 4304
WANG J. D. ET AL., ONCOLOGY, vol. 73, no. 3-4, 2007, pages 238 - 45
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SHITASHIGE M. ET AL., CANCER RES, vol. 70, no. 12, 2010, pages 5024 - 33
JIAO X. ET AL., BMC GENOMICS, vol. 14, 2013, pages 165
GARZON-MUVDI T. ET AL., PLOS BIOL, vol. 10, no. 5, 2012, pages E1001320
REVILLION F. ET AL., ANN ONCOL, vol. 19, no. 1, 2008, pages 73 - 80
TANIDA I.; TANIDA-MIYAKE E.; KOMATSU M.; UENO T.; KOMINAMI E.: "Human Apg3p/Autlp homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApgl2p to hApg5p", JBIOL CHEM., vol. 277, no. 16, 19 April 2002 (2002-04-19), pages 13739 - 44
VINDIS C.; CERRETTI D. P.; DANIEL T. O.; HUYNH-DO U.: "EphBl recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis", J CELL BIOL., vol. 162, no. 4, 18 August 2003 (2003-08-18), pages 661 - 71, XP002414039, DOI: doi:10.1083/jcb.200302073
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KAMURA T.; HARA T.; MATSUMOTO M.; ISHIDA N.; OKUMURA F.; HATAKEYAMA S.; YOSHIDA M.; NAKAYAMA K.; NAKAYAMA K. I.: "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kipl) at G1 phase", NAT CELL BIOL., vol. 6, no. 12, December 2004 (2004-12-01), pages 1229 - 35
KAMURA, T. ET AL., NATURE CELL BIOLOGY, vol. 6, no. 12, 2004, pages 1229 - 35
SOMASEKHARAN S.; TANIS J.; FORBUSH B.: "Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1", J BIOL CHEM., vol. 287, no. 21, 18 May 2012 (2012-05-18), pages 17308 - 17
CHANG H.; RIESE D. J. 2ND; GILBERT W.; STERN D. F.; MCMAHAN U. J.: "Ligands for ErbB-family receptors encoded by a neuregulin-like gene", NATURE, vol. 387, no. 6632, 29 May 1997 (1997-05-29), pages 509 - 12, XP002636460
CARRAWAY K. L. 3RD; WEBER J. L.; UNGER M. J.; LEDESMA J.; YU N.; GASSMANN M.; LAI C.: "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases", NATURE, vol. 387, no. 6632, 29 May 1997 (1997-05-29), pages 512 - 6, XP000919297, DOI: doi:10.1038/387512a0
HOBBS S. S.; COFFING S. L.; LE A. T.; CAMERON E. M.; WILLIAMS E. E.; ANDREW M.; BLOMMEL E. N.; HAMMER R. P.; CHANG H.; RIESE D. J.: "Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation", ONCOGENE, vol. 21, no. 55, 5 December 2002 (2002-12-05), pages 8442 - 52, XP009053189, DOI: doi:10.1038/sj.onc.1205960
NAKANO N.; HIGASHIYAMA S.; OHMOTO H.; ISHIGURO H.; TANIGUCHI N.; WADA Y.: "The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis", JBIOL CHERN., vol. 279, no. 12, 19 March 2004 (2004-03-19), pages 11465 - 70
WILSON, T. R. ET AL., CANCER CELL, vol. 20, 2011, pages 158 - 172
HO K. K. ET AL., BIOORG MED CHEM LETT, 2013, vol. 23, no. 2, 16 November 2012 (2012-11-16), pages 569 - 73
KRAMER, W.; FRITZ, H. J., METHODS ENZYMOL., vol. 154, 1987, pages 350
MEYERSON, M. ET AL., NAT. REV. GENET., vol. 11, 2010, pages 685 - 696
TAO JIONG ET AL.: "CD 44-SLC1A2 Gene Fusions in Gastric Cancer", SCIENCE TRANSLATIONAL MEDICINE, vol. 3, no. ISSUE, 2011, pages 1 - 11
ZANG ZHI JIANG ET AL.: "Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing", CANCER RESEARCH, vol. 71, no. 1, 2011, pages 29 - 39, XP055226664, DOI: doi:10.1158/0008-5472.CAN-10-1749
CHO GEUN-A ET AL.: "Abstract 5078: Identification of novel gene fusions by RNA-seq in gastric cancer", CANCER RESEARCH, vol. 72, no. SUPPL., 2012, pages 5078
YUN SUN MI: "Abstract 4304: PPP1R1B-STARD3 fusion gene promotes gastric tumorigenesis through activation of PI3K/Akt signaling.", CANCER RESEARCH, vol. 73, no. SUPPL., April 2013 (2013-04-01), pages 4304
WANG J. D. ET AL., ONCOLOGY, vol. 73, no. 3-4, 2007, pages 238 - 45
SHENG Z. ET AL., PATHOBIOLOGY, vol. 75, no. 5, 2008, pages 274 - 80
SHITASHIGE M. ET AL., CANCER RES, vol. 70, no. 12, 2010, pages 5024 - 33
JIAO X. ET AL., BMC GENOMICS, vol. 14, 2013, pages 165
GARZON-MUVDI T. ET AL., PLOS BIOL, vol. 10, no. 5, 2012, pages E1001320
REVILLION F. ET AL., ANN ONCOL, vol. 19, no. 1, 2008, pages 73 - 80
TANIDA I.; TANIDA-MIYAKE E.; KOMATSU M.; UENO T.; KOMINAMI E.: "Human Apg3p/Autlp homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApgl2p to hApg5p", JBIOL CHEM., vol. 277, no. 16, 19 April 2002 (2002-04-19), pages 13739 - 44
VINDIS C.; CERRETTI D. P.; DANIEL T. O.; HUYNH-DO U.: "EphBl recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis", J CELL BIOL., vol. 162, no. 4, 18 August 2003 (2003-08-18), pages 661 - 71, XP002414039, DOI: doi:10.1083/jcb.200302073
ALTSCHUL S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
FU C. A.; SHEN M.; HUANG B. C.; LASAGA J.; PAYAN D. G.; LUO Y.: "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton", J BIOL CHEM., vol. 274, no. 43, 22 October 1999 (1999-10-22), pages 30729 - 37, XP002173259, DOI: doi:10.1074/jbc.274.43.30729
MAHMOUDI T.; LI V. S.; NG S. S.; TAOUATAS N.; VRIES R. G.; MOHAMMED S.; HECK A. J.; CLEVERS H.: "The kinase TNIK is an essential activator of Wnt target genes", EMBOJ., vol. 28, no. 21, 4 November 2009 (2009-11-04), pages 3329 - 40, XP002644396, DOI: doi:10.1038/EMBOJ.2009.285
KAMURA T.; HARA T.; MATSUMOTO M.; ISHIDA N.; OKUMURA F.; HATAKEYAMA S.; YOSHIDA M.; NAKAYAMA K.; NAKAYAMA K. I.: "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kipl) at G1 phase", NAT CELL BIOL., vol. 6, no. 12, December 2004 (2004-12-01), pages 1229 - 35
KAMURA, T. ET AL., NATURE CELL BIOLOGY, vol. 6, no. 12, 2004, pages 1229 - 35
SOMASEKHARAN S.; TANIS J.; FORBUSH B.: "Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1", J BIOL CHEM., vol. 287, no. 21, 18 May 2012 (2012-05-18), pages 17308 - 17
CHANG H.; RIESE D. J. 2ND; GILBERT W.; STERN D. F.; MCMAHAN U. J.: "Ligands for ErbB-family receptors encoded by a neuregulin-like gene", NATURE, vol. 387, no. 6632, 29 May 1997 (1997-05-29), pages 509 - 12, XP002636460
CARRAWAY K. L. 3RD; WEBER J. L.; UNGER M. J.; LEDESMA J.; YU N.; GASSMANN M.; LAI C.: "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases", NATURE, vol. 387, no. 6632, 29 May 1997 (1997-05-29), pages 512 - 6, XP000919297, DOI: doi:10.1038/387512a0
HOBBS S. S.; COFFING S. L.; LE A. T.; CAMERON E. M.; WILLIAMS E. E.; ANDREW M.; BLOMMEL E. N.; HAMMER R. P.; CHANG H.; RIESE D. J.: "Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation", ONCOGENE, vol. 21, no. 55, 5 December 2002 (2002-12-05), pages 8442 - 52, XP009053189, DOI: doi:10.1038/sj.onc.1205960
NAKANO N.; HIGASHIYAMA S.; OHMOTO H.; ISHIGURO H.; TANIGUCHI N.; WADA Y.: "The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis", JBIOL CHERN., vol. 279, no. 12, 19 March 2004 (2004-03-19), pages 11465 - 70
WILSON, T. R. ET AL., CANCER CELL, vol. 20, 2011, pages 158 - 172
HO K. K. ET AL., BIOORG MED CHEM LETT, 2013, vol. 23, no. 2, 16 November 2012 (2012-11-16), pages 569 - 73
KRAMER, W.; FRITZ, H. J., METHODS ENZYMOL., vol. 154, 1987, pages 350
MEYERSON, M. ET AL., NAT. REV. GENET., vol. 11, 2010, pages 685 - 696
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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