Title:
NOVEL GADOLINIUM CHELATE OF CYCLIC STRUCTURE CONTAINING FERROCENE
Document Type and Number:
WIPO Patent Application WO/2012/070712
Kind Code:
A1
Abstract:
The present invention relates to a novel gadolinium chelate of cyclic structure containing ferrocene and more specifically to a new MRI contrast agent containing DTPA-bis(amide)-ferrocene having the structure of chemical formula 1 or derivative compounds thereof as a ligand. According to the invention, DTPA-bis(amide)-ferrocene or derivative compounds thereof can be prepared and a cyclic gadolinium complex can be prepared using said compounds. An MR (Magnetic Resonance) angiographic contrast agent containing the gadolinium complex that is prepared according to the invention as an active ingredient has a high magnetic relaxation rate in blood in addition to thermodynamic and kinetic stabilities when compared to other contrast agents currently in use, thereby enabling application as a more stable MR angiographic contrast agent capable of angiography.
Inventors:
KIM, Tae-Jeong (21Ho Prime Valley, 645-6 Sawol-ri Namsan-myeon Gyeongsan-si, Gyeongsangbuk-do 712-862, 712-862, KR)
김태정 (경상북도 경산시 남산면 사월리 645-6 프라임벨리 21호, 712-862 Gyeongsangbuk-do, 712-862, KR)
CHANG, Yong Min (103Ho New World Heights, 288-4 Samdeok-dong 2-ga Jung-gu, Daegu 700-412, 700-412, KR)
김태정 (경상북도 경산시 남산면 사월리 645-6 프라임벨리 21호, 712-862 Gyeongsangbuk-do, 712-862, KR)
CHANG, Yong Min (103Ho New World Heights, 288-4 Samdeok-dong 2-ga Jung-gu, Daegu 700-412, 700-412, KR)
Application Number:
KR2010/009150
Publication Date:
May 31, 2012
Filing Date:
December 21, 2010
Export Citation:
Assignee:
KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (Kyungpook National University, 1370 Sangyeok-dong Buk-gu, Daegu 702-701, 702-701, KR)
경북대학교 산학협력단 (대구광역시 북구 산격동 1370 경북대학교, 702-701 Daegu, 702-701, KR)
KIM, Tae-Jeong (21Ho Prime Valley, 645-6 Sawol-ri Namsan-myeon Gyeongsan-si, Gyeongsangbuk-do 712-862, 712-862, KR)
김태정 (경상북도 경산시 남산면 사월리 645-6 프라임벨리 21호, 712-862 Gyeongsangbuk-do, 712-862, KR)
경북대학교 산학협력단 (대구광역시 북구 산격동 1370 경북대학교, 702-701 Daegu, 702-701, KR)
KIM, Tae-Jeong (21Ho Prime Valley, 645-6 Sawol-ri Namsan-myeon Gyeongsan-si, Gyeongsangbuk-do 712-862, 712-862, KR)
김태정 (경상북도 경산시 남산면 사월리 645-6 프라임벨리 21호, 712-862 Gyeongsangbuk-do, 712-862, KR)
International Classes:
C07F17/02; A61K49/10
Attorney, Agent or Firm:
LEE, Moon-Sup (Suite 301 Chungdong Building, 1659-2 Inhundong Gwanak-gu, Seoul 151-832, 151-832, KR)
Claims: